Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis

被引：51

作者：

Oumzil, Khalid ^{[1
,2
]}

Ramin, Michael A. ^{[1
,2
]}

Lorenzato, Cyril ^{[3
]}

Hemadou, Audrey ^{[3
]}

Laroche, Jeanny ^{[3
]}

Jacobin-Valat, Marie Josee ^{[3
]}

Mornet, Stephane ^{[4
]}

Roy, Claude-Eric ^{[1
,2
]}

Kauss, Tina ^{[1
,2
]}

Gaudin, Karen ^{[1
,2
]}

Clofent-Sanchez, Gisele ^{[3
]}

Barthelemy, Philippe ^{[1
,2
]}

机构：

[1] Univ Bordeaux, ARNA Lab, F-33000 Bordeaux, France

[2] INSERM, ARNA Lab, U869, F-33000 Bordeaux, France

[3] Univ Bordeaux, CNRS, Ctr Resonance Magnet Syst Biol, UMR 5536, F-33076 Bordeaux, France

[4] Univ Bordeaux, Inst Chim Matiere Condensee Bordeaux, ICMCB UPR CNRS 9048, F-33608 Pessac, France

来源：

BIOCONJUGATE CHEMISTRY | 2016年 / 27卷 / 03期

关键词：

MAGNETIC-RESONANCE; IN-VIVO; CARDIOVASCULAR-DISEASE; DELIVERY; CANCER; PLAQUE; PROSTACYCLIN; MACROPHAGES; RECEPTOR; FUTURE;

D O I：

10.1021/acs.bioconjchem.5b00590

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.

引用

页码：569 / 575

页数：7

共 50 条

[1] Inorganic Nanoparticles for Image-Guided Therapy
Yoon, Hong Yeol
Jeon, Sangmin
You, Dong Gil
Park, Jae Hyung
Kwon, Ick Chan
Koo, Heebeom
Kim, Kwangmeyung
BIOCONJUGATE CHEMISTRY, 2017, 28 (01) : 124 - 134
[2] Gold nanoparticles in image-guided cancer therapy
Kim, Dongkyu
Jon, Sangyong
INORGANICA CHIMICA ACTA, 2012, 393 : 154 - 164
[3] Synthesis of Polymer-Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy
Mieszawska, Aneta J.
Kim, YongTae
Gianella, Anita
van Rooy, Inge
Priem, Bram
Labarre, Matthew P.
Ozcan, Canturk
Cormode, David P.
Petrov, Artiom
Langer, Robert
Farokhzad, Omid C.
Fayad, Zahi A.
Mulder, Willem J. M.
BIOCONJUGATE CHEMISTRY, 2013, 24 (09) : 1429 - 1434
[4] Image-guided interventional therapy for cancer with radiotherapeutic nanoparticles
Phillips, William T.
Bao, Ande
Brenner, Andrew J.
Goins, Beth A.
ADVANCED DRUG DELIVERY REVIEWS, 2014, 76 : 39 - 59
[5] AGuIX nanoparticles as a promising platform for image-guided radiation therapy
Detappe A.
Kunjachan S.
Rottmann J.
Robar J.
Tsiamas P.
Korideck H.
Tillement O.
Berbeco R.
Cancer Nanotechnology, 2015, 6 (1)
[6] Nanoparticles based image-guided thermal therapy and temperature feedback
Jacinto, Carlos
Silva, Wagner F.
Garcia, Joel
Zaragosa, Gelo P.
Ilem, Carlo Nonato D.
Sales, Tasso O.
Santos, Harrisson D. A.
Conde, Blessed Isaac C.
Barbosa, Helliomar Pereira
Malik, Sonia
Sharma, Surender Kumar
JOURNAL OF MATERIALS CHEMISTRY B, 2024, 13 (01) : 54 - 102
[7] Multi-functional nanoparticles for image-guided photothermal therapy
Li, Chun
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
[8] Image-guided radiation therapy
Poortmans, P.
Essers, M.
Osman, S.
Hol, S.
EUROPEAN JOURNAL OF CANCER, 2013, 49 : S35 - S36
[9] Image-guided thermal therapy
Hynynen, K
Vykhodtseva, N
McDannold, N
Bronson, R
Jolesz, F
RADIATION RESEARCH, VOL 2, CONGRESS PROCEEDINGS, 2000, : 845 - 848
[10] Image-guided therapy in urology
Chan, DY
Solomon, S
Kim, FJ
Jarret, TW
JOURNAL OF ENDOUROLOGY, 2001, 15 (01) : 105 - 110

← 1 2 3 4 5 →