Automation of biomolecular NMR screening

被引：8
|
作者：
Ross, A [1 ]
Senn, H [1 ]
机构：
[1] Hoffmann La Roche AG, Dept Biostruct Res, PRBT, CH-4070 Basel, Switzerland
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 01期
关键词：
NMR; ligand; protein; screening; automation; PCA;
D O I：
10.2174/1568026033392688
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
For NMR based screening we review equipment needed for automated preparation of samples and acquisition of a large number of data sets. Hardware connecting lab-bench and NMR spectrometer is described. We focus on software used for automated calculation of the similarity between spectra - a prerequisite for the identification of test compounds interacting with a target-molecule.
引用
收藏
页码：55 / 67
页数：13
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