Activatable Molecular Probes for Cancer Imaging

被引：75
|
作者：
Lee, Seulki [1 ]
Xie, Jin [1 ]
Chen, Xiaoyuan [1 ]
机构：
[1] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 11期
关键词：
RESONANCE ENERGY-TRANSFER; CELL-PENETRATING PEPTIDES; PROTEASE ACTIVITY; QUANTUM DOTS; FLUORESCENT PEPTIDE; APOPTOSIS; THERAPEUTICS; EXPRESSION; ANTIBODIES; PROTEINS;
D O I：
10.2174/156802610791384270
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The development of highly sensitive and specific molecular probes for cancer imaging still remains a daunting challenge. Recently, interdisciplinary research at the interface of imaging sciences and bionanoconjugation chemistry has generated novel activatable imaging probes that can provide high-resolution imaging with ultra-low background signals. Activatable imaging probes are designed to amplify output imaging signals in response to specific biomolecular recognition or environmental changes in real time. This review introduces and highlights the unique design strategies and applications of various activatable imaging probes in cancer imaging.
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页码：1135 / 1144
页数：10
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