Activatable Molecular Probes for Cancer Imaging

被引：75
|
作者：
Lee, Seulki [1 ]
Xie, Jin [1 ]
Chen, Xiaoyuan [1 ]
机构：
[1] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 11期
关键词：
RESONANCE ENERGY-TRANSFER; CELL-PENETRATING PEPTIDES; PROTEASE ACTIVITY; QUANTUM DOTS; FLUORESCENT PEPTIDE; APOPTOSIS; THERAPEUTICS; EXPRESSION; ANTIBODIES; PROTEINS;
D O I：
10.2174/156802610791384270
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The development of highly sensitive and specific molecular probes for cancer imaging still remains a daunting challenge. Recently, interdisciplinary research at the interface of imaging sciences and bionanoconjugation chemistry has generated novel activatable imaging probes that can provide high-resolution imaging with ultra-low background signals. Activatable imaging probes are designed to amplify output imaging signals in response to specific biomolecular recognition or environmental changes in real time. This review introduces and highlights the unique design strategies and applications of various activatable imaging probes in cancer imaging.
引用
下载
收藏
页码：1135 / 1144
页数：10
相关论文
共 50 条
  • [31] Enzyme Activity Imaging Using Activatable Raman Probes
    Fujioka, Hiroyoshi
    Kamiya, Mako
    BUNSEKI KAGAKU, 2023, 72 (12) : 511 - 521
  • [32] Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo
    Fu, Qinrui
    Yang, Xiao
    Wang, Mengzhen
    Zhu, Kang
    Wang, Yin
    Song, Jibin
    ACS NANO, 2024, 18 (05) : 3916 - 3968
  • [33] Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
    Luo, Pan
    Gao, Fu-Qiang
    Sun, Wei
    Li, Jun-You
    Wang, Cheng
    Zhang, Qing-Yu
    Li, Zhi-Zhuo
    Xu, Peng
    MILITARY MEDICAL RESEARCH, 2023, 10 (01)
  • [34] Applications of nanotechnology and molecular probes in cancer imaging
    Meade, T. J.
    EJC SUPPLEMENTS, 2008, 6 (12): : 148 - 148
  • [35] Hybrid Ferritin Nanoparticles as Activatable Probes for Tumor Imaging
    Lin, Xin
    Xie, Jin
    Zhu, Lei
    Lee, Seulki
    Niu, Gang
    Ma, Ying
    Kim, Kwangmeyung
    Chen, Xiaoyuan
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (07) : 1569 - 1572
  • [36] Light-activatable probes for cancer biology
    Beharry, Andrew
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [37] Molecular Imaging with Activatable Reporter Systems
    Niu, Gang
    Chen, Xiaoyuan
    THERANOSTICS, 2012, 2 (04): : 413 - 423
  • [38] Activatable Small Molecule Probes for Photoacoustic Imaging: Dyes and Applications
    Merkes, Jean Michel
    Kiessling, Fabian
    Banala, Srinivas
    CURRENT MEDICINAL CHEMISTRY, 2022, 29 (39) : 6008 - 6029
  • [39] Targeting cancer stem cells with molecular imaging probes
    Bearrood, Thomas
    Anorma, Chelsea
    Pino, Nicholas
    Dibrell, Sara
    Chan, Jefferson
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [40] Dual-Targeted Molecular Probes for Cancer Imaging
    Liu, Zhaofei
    Wang, Fan
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2010, 11 (06) : 610 - 619
12345