One-Pot Sequential N-Heterocyclic Carbene/Rhodium(III) Catalysis: Synthesis of Fused Polycyclic Isocoumarins

被引：36

作者：

Youn, So Won ^{[1
,2
]}

Yoo, Huen Ji ^{[1
,2
]}

机构：

[1] Hanyang Univ, Dept Chem, Ctr New Direct Organ Synth, Seoul 04763, South Korea

[2] Hanyang Univ, Inst Mat Design, Seoul 04763, South Korea

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 13期

基金：

新加坡国家研究基金会;

关键词：

benzo-fused lactones; C-H activation; one-pot sequential catalysis; organocatalysis; rhodium catalysis; C-H ACTIVATION; OXIDATIVE CYCLIZATION; DUAL CATALYSIS; BENZOIC-ACIDS; REGIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; AROMATIC-ALDEHYDES; BOND ALKENYLATIONS; CARBOXYLIC-ACIDS; NATURAL-PRODUCTS;

D O I：

10.1002/adsc.201700072

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A one-pot sequential N-heterocyclic carbene-rhodium (NHC-Rh) catalysis is described, demonstrating the compatibility of NHC and Rh catalysts. N-Heterocyclic carbene-catalyzed aerobic oxidation of benzaldehydes and subsequent rhodium(III)-catalyzed oxidative coupling/ annulation with multiple bonds enabled the formation of two C-O bonds and one C-C bond in a single pot. This operationally easy, one-pot protocol under air provides access to a diverse array of valuable fused polycyclic isocoumarins.

引用

页码：2176 / 2183

页数：8

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