N-Heterocyclic Carbene (NHC) Organocatalytic One-Pot Reaction for the Enantioselective Synthesis of Fluoromethylated Chromenones

被引：12
|
作者：
Wang, Baoxu [1 ]
Huang, Liangsen [1 ]
Hou, Yuchen [1 ]
Lan, Shouang [1 ]
Cheng, Jiajia [1 ,2 ]
机构：
[1] Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China
[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 19期
基金：
中国国家自然科学基金;
关键词：
INTRAMOLECULAR STETTER REACTION; BOND-FORMING REACTIONS; ASYMMETRIC ORGANOCATALYSIS; CATALYZED HYDROACYLATION; CHEMISTRY; FLUORINE; AZOLIUM; ACYL; CYCLOHEXADIENONES; DESYMMETRIZATION;
D O I：
10.1021/acs.orglett.8b02300
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient carbene organocatalyzed route to enantioenriched chromenones, bearing one tri- or difluoromethylated stereogenic center in the beta position of the carbonyl group, from o-allyloxybenzaldehydes is described. The one-pot transition-metal-free transformation exhibits a broad substrate scope and excellent enantioselectivity.
引用
收藏
页码：6012 / 6016
页数：5
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