Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction

被引：27
|
作者：
Zhong, Hai-Jing [1 ]
Lee, Bo Ra [3 ]
Boyle, Joshua William [3 ]
Wang, Wanhe [2 ]
Ma, Dik-Lung [2 ]
Chan, Philip Wai Hong [3 ,4 ]
Leung, Chung-Hang [1 ]
机构：
[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
[2] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
[3] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia
[4] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 34期
基金：
澳大利亚研究理事会; 中国国家自然科学基金;
关键词：
HISTONE MODIFICATIONS; LEUKEMIA; PROTEINS; DISCOVERY; FAMILY; CANCER; GENES; SET1;
D O I：
10.1039/c6cc01079b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.
引用
收藏
页码：5788 / 5791
页数：4
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