Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

被引：0

作者：

Jolanta Grembecka

Shihan He

Aibin Shi

Trupta Purohit

Andrew G Muntean

Roderick J Sorenson

Hollis D Showalter

Marcelo J Murai

Amalia M Belcher

Thomas Hartley

Jay L Hess

Tomasz Cierpicki

机构：

[1] University of Michigan,Department of Pathology

[2] University of Michigan,Department of Medicinal Chemistry

[3] University of Virginia,undefined

来源：

Nature Chemical Biology | 2012年 / 8卷 / 3期

关键词：

D O I：

10.1038/nchembio.773

中图分类号：

学科分类号：

摘要：

MLL fusion genes often encode leukemogenic proteins that depend on interaction with menin, a component of the MLL SET1-like histone methyltransferase complex. MI-2 and MI-3 are the first small molecules that can block menin–MLL fusion protein interaction and their oncogenic effects in cells.[graphic not available: see fulltext]

引用

页码：277 / 284

页数：7

共 50 条

[1] Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Grembecka, Jolanta
He, Shihan
Shi, Aibin
Purohit, Trupta
Muntean, Andrew G.
Sorenson, Roderick J.
Showalter, Hollis D.
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NATURE CHEMICAL BIOLOGY, 2012, 8 (03) : 277 - 284
[2] High-affinity small molecule inhibitors of the menin-MLL interaction reverse oncogenic transformation mediated by MLL fusion proteins in leukemia
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[5] Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia
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[10] Design and optimization of small molecule inhibitors blocking the menin-MLL interaction
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ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253

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