Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017

被引：5
|
作者：
Nagy, Alexander [1 ]
Dan, Adam [2 ]
Cernikova, Lenka [1 ]
Vitaskova, Elika [1 ]
Krivda, Vlastimil [1 ]
Hornickova, Jitka [1 ]
Masopust, Roman [1 ]
Sedlak, Kamil [1 ]
机构：
[1] State Vet Inst Prague, Sidlistni 136-24, Prague 16503, Czech Republic
[2] Vet Diagnost Inst, Natl Food Chain Safety Off, Tabornok Utca 2, H-1143 Budapest, Hungary
来源：
ARCHIVES OF VIROLOGY | 2018年 / 163卷 / 08期
关键词：
VIRUSES; POULTRY; NUMBERS;
D O I：
10.1007/s00705-018-3833-7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.
引用
收藏
页码：2219 / 2224
页数：6
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