Adaptation and conservation insights from the koala genome

被引：153

作者：

Johnson, Rebecca N. ^{[1
,2
]}

O'Meally, Denis ^{[2
,3
]}

Chen, Zhiliang ^{[4
]}

Etherington, Graham J. ^{[5
]}

Ho, Simon Y. W. ^{[2
]}

Nash, Will J. ^{[5
]}

Grueber, Catherine E. ^{[2
,6
]}

Cheng, Yuanyuan ^{[2
,7
]}

Whittington, Camilla M. ^{[8
]}

Dennison, Siobhan ^{[1
]}

Peel, Emma ^{[2
]}

Haerty, Wilfried ^{[5
]}

O'Neill, Rachel J. ^{[9
,10
]}

Colgan, Don ^{[1
]}

Russell, Tonia L. ^{[11
]}

Alquezar-Planas, David E. ^{[1
]}

Attenbrow, Val ^{[1
]}

Bragg, Jason G. ^{[12
,13
]}

Brandies, Parice A. ^{[2
]}

Chong, Amanda Yoon-Yee ^{[14
]}

Deakin, Janine E. ^{[15
]}

Di Palma, Federica ^{[5
,16
]}

Duda, Zachary ^{[9
,10
]}

Eldridge, Mark D. B. ^{[1
]}

Ewart, Kyle M. ^{[1
]}

Hogg, Carolyn J. ^{[2
]}

Frankham, Greta J. ^{[1
]}

Georges, Arthur ^{[15
]}

Gillett, Amber K. ^{[17
]}

Govendir, Merran ^{[8
]}

Greenwood, Alex D. ^{[18
,19
]}

Hayakawa, Takashi ^{[20
,21
]}

Helgen, Kristofer M. ^{[1
,22
,23
]}

Hobbs, Matthew ^{[1
]}

Holleley, Clare E. ^{[24
]}

Heider, Thomas N. ^{[9
,10
]}

Jones, Elizabeth A. ^{[8
]}

King, Andrew ^{[1
]}

Madden, Danielle ^{[3
]}

Graves, Jennifer A. Marshall ^{[12
,25
]}

Morris, Katrina M. ^{[26
,27
]}

Neaves, Linda E. ^{[1
,28
]}

Patel, Hardip R. ^{[29
]}

Polkinghorne, Adam ^{[3
]}

Renfree, Marilyn B. ^{[30
]}

Robin, Charles ^{[30
]}

Salinas, Ryan ^{[4
]}

Tsangaras, Kyriakos ^{[31
]}

Waters, Paul D. ^{[4
]}

Waters, Shafagh A. ^{[4
]}

机构：

[1] Australian Museum Res Inst, Australian Museum, Sydney, NSW, Australia

[2] Univ Sydney, Sch Life & Environm Sci, Fac Sci, Sydney, NSW, Australia

[3] Univ Sunshine Coast, Anim Res Ctr, Fac Sci Hlth Educ & Engn, Maroochydore, Qld, Australia

[4] Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW, Australia

[5] Earlham Inst, Norwich Res Pk, Norwich, Norfolk, England

[6] San Diego Zoo Global, San Diego, CA USA

[7] Univ Queensland, UQ Genom Initiat, St Lucia, Qld, Australia

[8] Univ Sydney, Sydney Sch Vet Sci, Fac Sci, Sydney, NSW, Australia

[9] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT USA

[10] Univ Connecticut, Inst Syst Gen, Storrs, CT USA

[11] Univ New South Wales, Ramaciotti Ctr Genom, Kensington, NSW, Australia

[12] Australian Natl Univ, Res Sch Biol, Canberra, ACT, Australia

[13] Natl Herbarium New South Wales, Royal Bot Gardens & Domain Trust, Sydney, NSW, Australia

[14] Univ Oxford, Nuffield Dept Med, Wellcome Ctr Human Genet, Oxford, England

[15] Univ Canberra, Inst Appl Ecol, Bruce, ACT, Australia

[16] Univ East Anglia, Dept Biol Sci, Norwich, Norfolk, England

[17] Australia Zoo Wildlife Hosp, Beerwah, Qld, Australia

[18] Leibniz Inst Zoo & Wildlife Res, Dept Wildlife Dis, Berlin, Germany

[19] Free Univ Berlin, Dept Vet Med, Berlin, Germany

[20] Kyoto Univ, Dept Wildlife Sci, Nagoya Railroad Co Ltd, Inuyama, Aichi, Japan

[21] Japan Monkey Ctr, Inuyama, Aichi, Japan

[22] Univ Adelaide, Sch Biol Sci, Environm Inst, Ctr Appl Conservat Sci, Adelaide, SA, Australia

[23] Univ Adelaide, ARC Ctr Excellence Australian Biodivers & Heritag, Adelaide, SA, Australia

[24] CSIRO, Natl Res Collect Australia, Australian Natl Wildlife Collect, Canberra, ACT, Australia

[25] La Trobe Univ, Sch Life Sci, Victoria, Bundoora, Vic, Australia

[26] Univ Edinburgh, Roslin Inst, Easter Bush, Midlothian, Scotland

[27] Univ Edinburgh, R D SVS, Easter Bush, Midlothian, Scotland

[28] Royal Bot Garden Edinburgh, Edinburgh, Midlothian, Scotland

[29] Australian Natl Univ, John Curtin Sch Med Res, Acton, ACT, Australia

[30] Univ Melbourne, Sch Biosci, Melbourne, Vic, Australia

[31] Cyprus Inst Neurol & Genet, Dept Translat Genet, Nicosia, Cyprus

[32] Univ Sunshine Coast, Fac Sci Hlth Educ & Engn, Maroochydore, Qld, Australia

来源：

NATURE GENETICS | 2018年 / 50卷 / 08期

基金：

英国生物技术与生命科学研究理事会; 澳大利亚研究理事会; 美国国家科学基金会;

关键词：

PLANT SECONDARY METABOLITES; PHASCOLARCTOS-CINEREUS; MICROSOMAL METABOLISM; CHLAMYDIAL INFECTIONS; TRICHOSURUS-VULPECULA; POPULATION TRENDS; TASMANIAN DEVIL; RECEPTOR GENES; SEQUENCE; DNA;

D O I：

10.1038/s41588-018-0153-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as 'vulnerable' due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala's ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala's survival in the wild.

引用

页码：1102 / +

页数：17

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