Adaptation and conservation insights from the koala genome

被引：153

作者：

Johnson, Rebecca N. ^{[1
,2
]}

O'Meally, Denis ^{[2
,3
]}

Chen, Zhiliang ^{[4
]}

Etherington, Graham J. ^{[5
]}

Ho, Simon Y. W. ^{[2
]}

Nash, Will J. ^{[5
]}

Grueber, Catherine E. ^{[2
,6
]}

Cheng, Yuanyuan ^{[2
,7
]}

Whittington, Camilla M. ^{[8
]}

Dennison, Siobhan ^{[1
]}

Peel, Emma ^{[2
]}

Haerty, Wilfried ^{[5
]}

O'Neill, Rachel J. ^{[9
,10
]}

Colgan, Don ^{[1
]}

Russell, Tonia L. ^{[11
]}

Alquezar-Planas, David E. ^{[1
]}

Attenbrow, Val ^{[1
]}

Bragg, Jason G. ^{[12
,13
]}

Brandies, Parice A. ^{[2
]}

Chong, Amanda Yoon-Yee ^{[14
]}

Deakin, Janine E. ^{[15
]}

Di Palma, Federica ^{[5
,16
]}

Duda, Zachary ^{[9
,10
]}

Eldridge, Mark D. B. ^{[1
]}

Ewart, Kyle M. ^{[1
]}

Hogg, Carolyn J. ^{[2
]}

Frankham, Greta J. ^{[1
]}

Georges, Arthur ^{[15
]}

Gillett, Amber K. ^{[17
]}

Govendir, Merran ^{[8
]}

Greenwood, Alex D. ^{[18
,19
]}

Hayakawa, Takashi ^{[20
,21
]}

Helgen, Kristofer M. ^{[1
,22
,23
]}

Hobbs, Matthew ^{[1
]}

Holleley, Clare E. ^{[24
]}

Heider, Thomas N. ^{[9
,10
]}

Jones, Elizabeth A. ^{[8
]}

King, Andrew ^{[1
]}

Madden, Danielle ^{[3
]}

Graves, Jennifer A. Marshall ^{[12
,25
]}

Morris, Katrina M. ^{[26
,27
]}

Neaves, Linda E. ^{[1
,28
]}

Patel, Hardip R. ^{[29
]}

Polkinghorne, Adam ^{[3
]}

Renfree, Marilyn B. ^{[30
]}

Robin, Charles ^{[30
]}

Salinas, Ryan ^{[4
]}

Tsangaras, Kyriakos ^{[31
]}

Waters, Paul D. ^{[4
]}

Waters, Shafagh A. ^{[4
]}

机构：

[1] Australian Museum Res Inst, Australian Museum, Sydney, NSW, Australia

[2] Univ Sydney, Sch Life & Environm Sci, Fac Sci, Sydney, NSW, Australia

[3] Univ Sunshine Coast, Anim Res Ctr, Fac Sci Hlth Educ & Engn, Maroochydore, Qld, Australia

[4] Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW, Australia

[5] Earlham Inst, Norwich Res Pk, Norwich, Norfolk, England

[6] San Diego Zoo Global, San Diego, CA USA

[7] Univ Queensland, UQ Genom Initiat, St Lucia, Qld, Australia

[8] Univ Sydney, Sydney Sch Vet Sci, Fac Sci, Sydney, NSW, Australia

[9] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT USA

[10] Univ Connecticut, Inst Syst Gen, Storrs, CT USA

[11] Univ New South Wales, Ramaciotti Ctr Genom, Kensington, NSW, Australia

[12] Australian Natl Univ, Res Sch Biol, Canberra, ACT, Australia

[13] Natl Herbarium New South Wales, Royal Bot Gardens & Domain Trust, Sydney, NSW, Australia

[14] Univ Oxford, Nuffield Dept Med, Wellcome Ctr Human Genet, Oxford, England

[15] Univ Canberra, Inst Appl Ecol, Bruce, ACT, Australia

[16] Univ East Anglia, Dept Biol Sci, Norwich, Norfolk, England

[17] Australia Zoo Wildlife Hosp, Beerwah, Qld, Australia

[18] Leibniz Inst Zoo & Wildlife Res, Dept Wildlife Dis, Berlin, Germany

[19] Free Univ Berlin, Dept Vet Med, Berlin, Germany

[20] Kyoto Univ, Dept Wildlife Sci, Nagoya Railroad Co Ltd, Inuyama, Aichi, Japan

[21] Japan Monkey Ctr, Inuyama, Aichi, Japan

[22] Univ Adelaide, Sch Biol Sci, Environm Inst, Ctr Appl Conservat Sci, Adelaide, SA, Australia

[23] Univ Adelaide, ARC Ctr Excellence Australian Biodivers & Heritag, Adelaide, SA, Australia

[24] CSIRO, Natl Res Collect Australia, Australian Natl Wildlife Collect, Canberra, ACT, Australia

[25] La Trobe Univ, Sch Life Sci, Victoria, Bundoora, Vic, Australia

[26] Univ Edinburgh, Roslin Inst, Easter Bush, Midlothian, Scotland

[27] Univ Edinburgh, R D SVS, Easter Bush, Midlothian, Scotland

[28] Royal Bot Garden Edinburgh, Edinburgh, Midlothian, Scotland

[29] Australian Natl Univ, John Curtin Sch Med Res, Acton, ACT, Australia

[30] Univ Melbourne, Sch Biosci, Melbourne, Vic, Australia

[31] Cyprus Inst Neurol & Genet, Dept Translat Genet, Nicosia, Cyprus

[32] Univ Sunshine Coast, Fac Sci Hlth Educ & Engn, Maroochydore, Qld, Australia

来源：

NATURE GENETICS | 2018年 / 50卷 / 08期

基金：

英国生物技术与生命科学研究理事会; 澳大利亚研究理事会; 美国国家科学基金会;

关键词：

PLANT SECONDARY METABOLITES; PHASCOLARCTOS-CINEREUS; MICROSOMAL METABOLISM; CHLAMYDIAL INFECTIONS; TRICHOSURUS-VULPECULA; POPULATION TRENDS; TASMANIAN DEVIL; RECEPTOR GENES; SEQUENCE; DNA;

D O I：

10.1038/s41588-018-0153-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as 'vulnerable' due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala's ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala's survival in the wild.

引用

页码：1102 / +

页数：17

共 50 条

[21] The Sinocyclocheilus cavefish genome provides insights into cave adaptation
Yang, Junxing
Chen, Xiaoli
Bai, Jie
Fang, Dongming
Qiu, Ying
Jiang, Wansheng
Yuan, Hui
Bian, Chao
Lu, Jiang
He, Shiyang
Pan, Xiaofu
Zhang, Yaolei
Wang, Xiaoai
You, Xinxin
Wang, Yongsi
Sun, Ying
Mao, Danqing
Liu, Yong
Fan, Guangyi
Zhang, He
Chen, Xiaoyong
Zhang, Xinhui
Zheng, Lanping
Wang, Jintu
Cheng, Le
Chen, Jieming
Ruan, Zhiqiang
Li, Jia
Yu, Hui
Peng, Chao
Ma, Xingyu
Xu, Junmin
He, You
Xu, Zhengfeng
Xu, Pao
Wang, Jian
Yang, Huanming
Wang, Jun
Whitten, Tony
Xu, Xun
Shi, Qiong
BMC BIOLOGY, 2016, 14
[22] The Sinocyclocheilus cavefish genome provides insights into cave adaptation
Junxing Yang
Xiaoli Chen
Jie Bai
Dongming Fang
Ying Qiu
Wansheng Jiang
Hui Yuan
Chao Bian
Jiang Lu
Shiyang He
Xiaofu Pan
Yaolei Zhang
Xiaoai Wang
Xinxin You
Yongsi Wang
Ying Sun
Danqing Mao
Yong Liu
Guangyi Fan
He Zhang
Xiaoyong Chen
Xinhui Zhang
Lanping Zheng
Jintu Wang
Le Cheng
Jieming Chen
Zhiqiang Ruan
Jia Li
Hui Yu
Chao Peng
Xingyu Ma
Junmin Xu
You He
Zhengfeng Xu
Pao Xu
Jian Wang
Huanming Yang
Jun Wang
Tony Whitten
Xun Xu
Qiong Shi
BMC Biology, 14
[23] Insights into the differentiation and adaptation within Circaeasteraceae from Circaeaster agrestis genome sequencing and resequencing
Sun, Yanxia
Zhang, Aidi
Zhang, Xu
Landis, Jacob B.
Zhang, Huajie
Zhang, Xiujun
Sun, Hang
Wang, Hengchang
ISCIENCE, 2023, 26 (03)
[24] Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes
Paul, Sandip
Bag, Sumit K.
Das, Sabyasachi
Harvill, Eric T.
Dutta, Chitra
GENOME BIOLOGY, 2008, 9 (04)
[25] Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes
Sandip Paul
Sumit K Bag
Sabyasachi Das
Eric T Harvill
Chitra Dutta
Genome Biology, 9
[26] Linking landscape ecology to planning for koala conservation
Rhodes, Jonathan
McAlpine, Clive
Peterson, Ann
Callaghan, John
Lunney, Daniel
Possingham, Hugh
Mitchell, David
Curran, Tim
AUSTRALIAN PLANNER, 2008, 45 (02) : 24 - 25
[27] Koala conservation policy process: Appraisal and recommendations
Clark, TW
Mazur, N
Cork, SJ
Dovers, S
Harding, R
CONSERVATION BIOLOGY, 2000, 14 (03) : 681 - 690
[28] Improving habitat models and their utility in koala conservation
Cork, SJ
Hume, LD
Foley, WJ
CONSERVATION BIOLOGY, 2000, 14 (03) : 660 - 668
[29] A transcriptome resource for the koala (Phascolarctos cinereus): insights into koala retrovirus transcription and sequence diversity
Matthew Hobbs
Ana Pavasovic
Andrew G King
Peter J Prentis
Mark DB Eldridge
Zhiliang Chen
Donald J Colgan
Adam Polkinghorne
Marc R Wilkins
Cheyne Flanagan
Amber Gillett
Jon Hanger
Rebecca N Johnson
Peter Timms
BMC Genomics, 15
[30] Koala retrovirus: a genome invasion in real time
Stoye, Jonathan P.
GENOME BIOLOGY, 2006, 7 (11)

← 1 2 3 4 5 →