Brain-derived neurotrophic factor (BDNF) in perinatal depression: Side show or pivotal factor?

被引：15

作者：

Singh, Saumya ^{[1
]}

Fereshetyan, Katarine ^{[2
]}

Shorter, Susan ^{[1
]}

Paliokha, Ruslan ^{[3
]}

Dremencov, Eliyahu ^{[3
]}

Yenkoyan, Konstantin ^{[2
]}

Ovsepian, Saak, V ^{[1
]}

机构：

[1] Univ Greenwich London, Fac Sci & Engn, Kent ME4 4TB, England

[2] Yerevan State Med Univ M Heratsi, Cobrain Ctr, Neurosci Lab, Yerevan 0025, Armenia

[3] Slovak Acad Sci, Ctr Biosci, Bratislava, Slovakia

来源：

DRUG DISCOVERY TODAY | 2022年 / 28卷 / 02期

关键词：

TrkB receptor; postpartum depression; fluid biomarker; estradiol; perinatal affective disorder; neuroplastic-ity; pregnancy; MATERNAL DEPRESSION; HUMAN PLATELETS; SEX-HORMONES; IN-VITRO; PREGNANCY; EXPRESSION; GROWTH; ESTROGEN; STRESS; CELLS;

D O I：

10.1016/j.drudis.2022.103467

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Perinatal depression is the most common psychiatric complication of pregnancy, with its detrimental effects on maternal and infant health widely underrated. There is a pressing need for specific molecular biomarkers, with pregnancy-related decline in brain-derived neurotrophic factor (BDNF) in the blood and downregulation of TrkB receptor in the brain reported in clinical and preclinical studies. In this review, we explore the emerging role of BDNF in reproductive biology and discuss evidence suggesting its deficiency as a risk factor for perinatal depression. With the increasing evidence for restoration of serum BDNF levels by antidepressant therapy, the strengthening association of perinatal depression with deficiency of BDNF supports its potential as a surrogate endpoint for preclinical and clinical studies.

引用

页数：7

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