Brain-derived neurotrophic factor (BDNF) in perinatal depression: Side show or pivotal factor?

被引：15
|
作者：
Singh, Saumya [1 ]
Fereshetyan, Katarine [2 ]
Shorter, Susan [1 ]
Paliokha, Ruslan [3 ]
Dremencov, Eliyahu [3 ]
Yenkoyan, Konstantin [2 ]
Ovsepian, Saak, V [1 ]
机构：
[1] Univ Greenwich London, Fac Sci & Engn, Kent ME4 4TB, England
[2] Yerevan State Med Univ M Heratsi, Cobrain Ctr, Neurosci Lab, Yerevan 0025, Armenia
[3] Slovak Acad Sci, Ctr Biosci, Bratislava, Slovakia
来源：
DRUG DISCOVERY TODAY | 2022年 / 28卷 / 02期
关键词：
TrkB receptor; postpartum depression; fluid biomarker; estradiol; perinatal affective disorder; neuroplastic-ity; pregnancy; MATERNAL DEPRESSION; HUMAN PLATELETS; SEX-HORMONES; IN-VITRO; PREGNANCY; EXPRESSION; GROWTH; ESTROGEN; STRESS; CELLS;
D O I：
10.1016/j.drudis.2022.103467
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Perinatal depression is the most common psychiatric complication of pregnancy, with its detrimental effects on maternal and infant health widely underrated. There is a pressing need for specific molecular biomarkers, with pregnancy-related decline in brain-derived neurotrophic factor (BDNF) in the blood and downregulation of TrkB receptor in the brain reported in clinical and preclinical studies. In this review, we explore the emerging role of BDNF in reproductive biology and discuss evidence suggesting its deficiency as a risk factor for perinatal depression. With the increasing evidence for restoration of serum BDNF levels by antidepressant therapy, the strengthening association of perinatal depression with deficiency of BDNF supports its potential as a surrogate endpoint for preclinical and clinical studies.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Brain-derived neurotrophic factor (BDNF) and susceptibility to functional psychosis
    Cordeiro, Q
    Michelon, L
    Sartorelli, A
    Destro, HM
    Miguita, K
    Vallada, H
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 130B (01) : 126 - 126
  • [22] The role of the brain-derived neurotrophic factor (BDNF) in anorexia nervosa
    Trinh, Stefanie
    Keller, Lara
    Herpertz-Dahlmann, Beate
    Seitz, Jochen
    PSYCHONEUROENDOCRINOLOGY, 2023, 151
  • [23] Brain-derived neurotrophic factor BDNF - Treatment of ALS antidiabetic
    不详
    DRUGS OF THE FUTURE, 2000, 25 (09) : 964 - 965
  • [24] The role of brain-derived neurotrophic factor (BDNF) in cognitive functions
    Silakarma, Dedi
    Sudewi, Anak Agung Raka
    BALI MEDICAL JOURNAL, 2019, 8 (02) : 427 - 434
  • [25] Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
    Krabbe, K. S.
    Nielsen, A. R.
    Krogh-Madsen, R.
    Plomgaard, P.
    Rasmussen, P.
    Erikstrup, C.
    Fischer, C. P.
    Lindegaard, B.
    Petersen, A. M. W.
    Taudorf, S.
    Secher, N. H.
    Pilegaard, H.
    Bruunsgaard, H.
    Pedersen, B. K.
    DIABETOLOGIA, 2007, 50 (02) : 431 - 438
  • [26] Brain-derived neurotrophic factor (BDNF) in stress and affective disorders
    J Licinio
    M-L Wong
    Molecular Psychiatry, 2002, 7 : 519 - 519
  • [27] Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
    K. S. Krabbe
    A. R. Nielsen
    R. Krogh-Madsen
    P. Plomgaard
    P. Rasmussen
    C. Erikstrup
    C. P. Fischer
    B. Lindegaard
    A. M. W. Petersen
    S. Taudorf
    N. H. Secher
    H. Pilegaard
    H. Bruunsgaard
    B. K. Pedersen
    Diabetologia, 2007, 50 : 431 - 438
  • [28] Effect of brain-derived neurotrophic factor (BDNF) on hepatocyte metabolism
    Genzer, Yoni
    Chapnik, Nava
    Froy, Oren
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2017, 88 : 69 - 74
  • [29] Circular pentapeptide mimetics of brain-derived neurotrophic factor (BDNF)
    Fletcher, J. M.
    Zwar, R. A.
    Hughes, R. A.
    BIOPOLYMERS, 2007, 88 (04) : 570 - 570
  • [30] Brain-derived neurotrophic factor (BDNF) in stress and affective disorders
    Licinio, J
    Wong, ML
    MOLECULAR PSYCHIATRY, 2002, 7 (06) : 519 - 519
12345