Enantioselective synthesis of a potential key intermediate for the total synthesis of fumagillin

被引：7
|
作者：
Ciampini, Marisa
Perlmutter, Patrick
Watson, Keith
机构：
[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia
[2] Monash Univ, Biota Holdings Inc, Clayton, Vic 3800, Australia
来源：
TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 02期
基金：
澳大利亚研究理事会;
关键词：
D O I：
10.1016/j.tetasy.2006.12.018
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Key intermediate, 7, of a projected total synthesis of the anti-angiogenesis compound Fumagillin 1 and the semi-synthetic analogue TNP-470 2, has been prepared in enantiornerically pure form by employing an early nucleophilic addition ring closure [NARC] sequence to construct the cyclohexene backbone. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.
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页码：243 / 250
页数：8
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