A concise route to a key intermediate in the total synthesis of sempervirine

被引：34

作者：

Rykowski, A

Lipinska, T

机构：

[1] Institute of Chemistry, Agricultural University at Siedlce

来源：

SYNTHETIC COMMUNICATIONS | 1996年 / 26卷 / 23期

关键词：

D O I：

10.1080/00397919608003843

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diels-Alder reaction of 5-acetyl-3-methylthio-1,2,4-triazine 3 with 1-pyrrolidino-1-cyclohexene afforded 3-acetyl-1-methylthio-5,6,7,8-teterahydroisoquinoline 4 which was readily converted into target 2-(3-(5,6,7,8-tetrahydroisoquinolinyl)) 6 via Fisher synthesis followed by reductive cleavage of the methylthio group in 5.

引用

页码：4409 / 4414

页数：6

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