The role of O-glycosylation in human disease

被引：84
|
作者：
Magalhaes, Ana [1 ,2 ]
Duarte, Henrique O. [1 ,2 ]
Reis, Celso A. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Porto, Inst Invest & Inovacao Saude I3S, Rua Alfredo Allen 208, P-4200135 Porto, Portugal
[2] Univ Porto, IPATIMUP Inst Patol & Imunol Mol, Porto, Portugal
[3] Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, Porto, Portugal
[4] Univ Porto, FMUP Fac Med, Porto, Portugal
来源：
MOLECULAR ASPECTS OF MEDICINE | 2021年 / 79卷
关键词：
Cancer; Cellular signaling; Glycan-based therapies; Glycosyltransferases; Infection; O-Glycans; ANTIGEN-PRESENTING CELLS; HELICOBACTER-PYLORI; EXTRACELLULAR VESICLES; T-CELLS; CORE; MOLECULAR-CLONING; SELECTIN LIGANDS; DENDRITIC CELLS; LECTIN DOMAINS; GLYCAN;
D O I：
10.1016/j.mam.2021.100964
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular glycosylation machinery, being organ-, tissue- and cell-specific. This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation. Particular relevance is given to genetic disorders of glycosylation, infectious diseases and cancer. Finally, we address the potential of O-glycans and their biosynthetic pathways as targets for novel therapeutic strategies.
引用
收藏
页数：10
相关论文
共 50 条
  • [41] Molecular Regulation of Protein O-Glycosylation and Relevance to Disease and Development
    Cummings, Richard D.
    Wang, Yingchun
    Ju, Tongzhong
    FASEB JOURNAL, 2013, 27
  • [42] Molecular regulation of protein O-glycosylation and functions in development and disease
    Cummings, RD
    FASEB JOURNAL, 2005, 19 (05): : A1711 - A1711
  • [43] IgA nephropathy is a disease of aberrant O-glycosylation with autoimmune features
    Hall, Stacy
    Coffee, Sarah
    Maillard, Nicolas
    Moldoveanu, Zina
    Craine, Ellenore
    Hargett, Audra A.
    Rizk, Dana V.
    Julian, Bruce A.
    Renfrow, Matthew B.
    Novak, Jan
    GLYCOBIOLOGY, 2021, 31 (12) : 1711 - 1712
  • [44] Toward Stable Genetic Engineering of Human O-Glycosylation in Plants
    Yang, Zhang
    Bennett, Eric P.
    Jorgensen, Bodil
    Drew, Damian P.
    Arigi, Emma
    Mandel, Ulla
    Ulvskov, Peter
    Levery, Steven B.
    Clausen, Henrik
    Petersen, Bent L.
    PLANT PHYSIOLOGY, 2012, 160 (01) : 450 - 463
  • [45] Aberrant O-glycosylation contributes to tumorigenesis in human colorectal cancer
    Jiang, Yuliang
    Liu, Zhe
    Xu, Feng
    Dong, Xichen
    Cheng, Yurong
    Hu, Yizhang
    Gao, Tianbo
    Liu, Jian
    Yang, Lei
    Jia, Xingyuan
    Qian, Haili
    Wen, Tao
    An, Guangyu
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22 (10) : 4875 - 4885
  • [46] N- and O-glycosylation Analysis of Human C1-inhibitor Reveals Extensive Mucin-type O-Glycosylation
    Stavenhagen, Kathrin
    Kayili, H. Mehmet
    Holst, Stephanie
    Koeleman, Carolien A. M.
    Engel, Ruchira
    Wouters, Diana
    Zeerleder, Sacha
    Salih, Bekir
    Wuhrer, Manfred
    MOLECULAR & CELLULAR PROTEOMICS, 2018, 17 (06) : 1225 - 1238
  • [47] Monitoring of immunoglobulin N- and O-glycosylation in health and disease
    de Haan, Noortje
    Falck, David
    Wuhrer, Manfred
    GLYCOBIOLOGY, 2020, 30 (04) : 226 - 240
  • [48] TEMPORAL ASPECTS OF THE N-GLYCOSYLATION AND O-GLYCOSYLATION OF HUMAN CHORIONIC-GONADOTROPIN
    HANOVER, JA
    ELTING, J
    MINTZ, GR
    LENNARZ, WJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1982, 257 (17) : 172 - 177
  • [49] Alcohol effect on mucin O-glycosylation
    Hothpet, Vishwanath-Reddy
    Bhat, Ganapati
    Bailey, Kristina
    Cheng, Pi-Wan
    GLYCOBIOLOGY, 2016, 26 (12) : 1438 - 1439
  • [50] Regulation of Notch Function by O-Glycosylation
    Harvey, Beth M.
    Haltiwanger, Robert S.
    MOLECULAR MECHANISMS OF NOTCH SIGNALING, 2018, 1066 : 59 - 78
12345