The role of O-glycosylation in human disease

被引：84
|
作者：
Magalhaes, Ana [1 ,2 ]
Duarte, Henrique O. [1 ,2 ]
Reis, Celso A. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Porto, Inst Invest & Inovacao Saude I3S, Rua Alfredo Allen 208, P-4200135 Porto, Portugal
[2] Univ Porto, IPATIMUP Inst Patol & Imunol Mol, Porto, Portugal
[3] Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, Porto, Portugal
[4] Univ Porto, FMUP Fac Med, Porto, Portugal
来源：
MOLECULAR ASPECTS OF MEDICINE | 2021年 / 79卷
关键词：
Cancer; Cellular signaling; Glycan-based therapies; Glycosyltransferases; Infection; O-Glycans; ANTIGEN-PRESENTING CELLS; HELICOBACTER-PYLORI; EXTRACELLULAR VESICLES; T-CELLS; CORE; MOLECULAR-CLONING; SELECTIN LIGANDS; DENDRITIC CELLS; LECTIN DOMAINS; GLYCAN;
D O I：
10.1016/j.mam.2021.100964
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular glycosylation machinery, being organ-, tissue- and cell-specific. This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation. Particular relevance is given to genetic disorders of glycosylation, infectious diseases and cancer. Finally, we address the potential of O-glycans and their biosynthetic pathways as targets for novel therapeutic strategies.
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页数：10
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