Copper-catalyzed annulation of 2-bromobenzoic esters with terminal alkynes towards 3-substituted isocoumarins

被引：17
|
作者：
Sun, Mengli [1 ]
Su, Lebin [1 ]
Dong, Jianyu [1 ]
Liu, Long [1 ]
Zhou, Yongbo [1 ]
Yin, Shuang-Feng [1 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 25期
关键词：
Isocoumarins; Copper catalysis; Terminal alkynes; 2-Bromobenzoic esters; O-IODOBENZOIC ACID; BENZOIC-ACIDS; REGIOSELECTIVE SYNTHESIS; ALPHA-PYRONES; OXIDATIVE CYCLIZATION; COUPLING REACTIONS; ARYL; PHTHALIDES; DERIVATIVES; BOND;
D O I：
10.1016/j.tetlet.2017.05.019
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of 3-substituted isocoumarins that are an important class of biologically active scaffolds via annulation of 2-bromobenzoic esters with terminal alkynes by copper catalyzed is described. The advantages of this method include mild reaction conditions, high yield and regioselectivity, and wide tolerance toward functional groups. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2433 / 2437
页数：5
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