Copper-catalyzed annulation of α-substituted diazoacetates with 2-ethynylanilines: the direct synthesis of C2-functionalized indoles

被引：26
|
作者：
Liu, Gang [1 ]
Xu, Guangyang [1 ]
Li, Jian [1 ]
Ding, Dong [1 ]
Sun, Jiangtao [1 ]
机构：
[1] Changzhou Univ, Sch Pharmaceut Engn & Life Sci, Changzhou 213164, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 09期
基金：
中国国家自然科学基金;
关键词：
2,3-DISUBSTITUTED INDOLES; CONCISE SYNTHESIS; FUNCTIONALIZATION; DERIVATIVES; CYCLIZATION; ALKALOIDS; 2-(AMINOMETHYL)INDOLES; ALKYLATION; INSERTION; ALCOHOLS;
D O I：
10.1039/c3ob42350f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed direct annulation of alpha-substituted diazoacetates with 2-ethynylanilines leading to C2-functionalized indoles was achieved under mild reaction conditions. The C2-(carboxylate methyl) substituted indoles were obtained in moderate to high yields. In addition, this procedure tolerates a series of N-substituted and free substituted 2-ethynylanilines.
引用
收藏
页码：1387 / 1390
页数：4
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