Facile synthesis of indoles by K2CO3 catalyzed cyclization reaction of 2-ethynylanilines in water

被引：20
|
作者：
Chen, Zhi [1 ]
Shi, Xiao-Xiao [1 ]
Ge, Dong-Qin [1 ]
Jiang, Zhen-Zhen [1 ]
Jin, Qi-Qi [1 ]
Jiang, Hua-Jiang [1 ]
Wu, Jia-Shou [1 ]
机构：
[1] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2017年 / 28卷 / 02期
基金：
中国国家自然科学基金;
关键词：
2-Ethynylanilines; Cyclization reaction; Indoles; Water; Potassium carbonate; NONREARRANGED MONOTERPENOID UNIT; MICROWAVE-ASSISTED SYNTHESIS; ORGANIC-SYNTHESIS; 2-SUBSTITUTED INDOLES; CONVENIENT SYNTHESIS; DERIVATIVES; ALKALOIDS; CYCLOISOMERIZATION; POTASSIUM; BASES;
D O I：
10.1016/j.cclet.2016.07.022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cyclization reaction of 2-ethynyl-N-sulfonylanilides proceeded efficiently in water with the presence of a catalytic amount of K2CO3 under transition metal-free condition to give indoles in high yields. The recovery and reusability of the present catalytic system were investigated. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：231 / 234
页数：4
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