High-contrast grating resonators for label-free detection of disease biomarkers

被引：53
|
作者：
Sun, Tianbo [1 ]
Kan, Shu [2 ]
Marriott, Gerard [2 ]
Chang-Hasnain, Connie [1 ]
机构：
[1] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
来源：
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词：
MYOCARDIAL-INFARCTION; DIAGNOSIS; SENSOR; ELISA;
D O I：
10.1038/srep27482
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of similar to 500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached antibodies with their respective antigens. The device can detect serum cardiac troponin I, a biomarker of cardiac disease to 100 pg/ml within 4 mins, which is faster, and as sensitive as current enzyme-linked immuno-assays for cTnI.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Ultrasensitive, label-free detection of cardiac biomarkers with optical SIS sensor
    Diware, Mangesh S.
    Cho, Hyun Mo
    Chegal, Won
    Cho, Yong Jai
    Kim, Dong Soo
    Won O, Sang
    Kim, Kyeong-Suk
    Paek, Se-Hwan
    BIOSENSORS & BIOELECTRONICS, 2017, 87 : 242 - 248
  • [22] A Rapid and Label-free SERS Detection Method for Biomarkers in Clinical Biofluids
    Kong, Kien Voon
    Leong, Weng Kee
    Lam, Zhiyong
    Gong, Tianxun
    Goh, Douglas
    Lau, Weber Kam On
    Olivo, Malini
    SMALL, 2014, 10 (24) : 5030 - 5034
  • [23] Label-free Monitoring of Alzheimer's Disease Biomarkers in Cerebrospinal Fluid
    Deng, Pan
    Song, Chao
    Que, Long
    2017 IEEE 17TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO), 2017, : 1074 - 1077
  • [24] Label-free methylation specific sensor based on silicon microring resonators for detection and quantification of DNA methylation biomarkers in bladder cancer
    Shin, Yong
    Perera, Agampodi Promoda
    Kee, Jack Sheng
    Song, Junfeng
    Fang, Qing
    Lo, Guo-Qiang
    Park, Mi Kyoung
    SENSORS AND ACTUATORS B-CHEMICAL, 2013, 177 : 404 - 411
  • [25] Biopatterning for label-free detection
    Goddard, Julie M.
    Mandal, Sudeep
    Nugen, Sam R.
    Baeumner, Antje J.
    Erickson, David
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2010, 76 (01) : 375 - 380
  • [26] Label-Free Detection Technologies
    McCarter, John D.
    COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2009, 12 (08) : 740 - 740
  • [27] Wafer-Scale Uniform Carbon Nanotube Transistors for Ultrasensitive and Label-Free Detection of Disease Biomarkers
    Liang, Yuqi
    Xiao, Mengmeng
    Wu, Ding
    Lin, Yanxia
    Liu, Lijun
    He, Jianping
    Zhang, Guojun
    Peng, Lian-Mao
    Zhang, Zhiyong
    ACS NANO, 2020, 14 (07) : 8866 - 8874
  • [28] Ptychography - label-free, high contrast and quantitative imaging of the cell cycle
    Suman, R.
    O'Toole, P.
    Langley, K.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
  • [29] Time-dependent high-contrast subwavelength resonators
    Ammari, Habib
    Hiltunen, Erik Orvehed
    JOURNAL OF COMPUTATIONAL PHYSICS, 2021, 445
  • [30] Label-free biological sensors based on ring resonators
    Delage, Andre
    Xu, Dan-Xia
    Densmore, Adam
    Janz, Siegfried
    Waldron, Philip
    Lapointe, Jean
    Lamontagne, Boris
    Mischki, Trevor
    Lopinski, Gregory
    Schmid, Jens
    Cheben, Pavel
    ICTON 2008: PROCEEDINGS OF 2008 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON TRANSPARENT OPTICAL NETWORKS, VOL 4, 2008, : 2 - +
12345