Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model

被引：42
|
作者：
Wang, Xiaojie [1 ,2 ]
Shi, Lei [2 ]
Tu, Qingfeng [2 ]
Wang, Hongwei [3 ]
Zhang, Haiyan [2 ]
Wang, Peiru [2 ]
Zhang, Linglin [2 ]
Huang, Zheng [4 ]
Zhao, Feng [5 ]
Luan, Hansen [5 ]
Wang, Xiuli [2 ]
机构：
[1] Anhui Med Univ, Shanghai Skin Dis Clin Coll, Hefei, Peoples R China
[2] Shanghai Skin Dis Hosp, Shanghai 200443, Peoples R China
[3] Fudan Univ, Huadong Hosp, Shanghai 200433, Peoples R China
[4] Fujian Normal Univ, MOE Key Lab OptoElect Sci & Technol Med, Fuzhou, Peoples R China
[5] China State Inst Pharmaceut Ind, Natl Pharmaceut Engn Res Ctr, Shanghai, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2015年 / 10卷
基金：
中国国家自然科学基金;
关键词：
5-aminolevulinic acid (ALA); polylactic-co-glycolic acid (PLGA); nanoparticles (NPs); cutaneous squamous cell carcinoma (SCC); photodynamic therapy (PDT); microneedling; TRANSDERMAL DRUG-DELIVERY; IN-VITRO; MICROFABRICATED MICRONEEDLES; SKIN PENETRATION; VIVO; GUIDELINES; EFFICIENT; CARRIER; CANCER; MEMORY;
D O I：
10.2147/IJN.S71245
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Background: Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC. Materials and methods: Ultraviolet-induced cutaneous SCCs were established in hairless mice. ALA-loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NP-induced protoporphyrin IX fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined. Results: PLGA NPs enhanced protoporphyrin IX production in SCC. ALA PLGA NP-mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC. Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.
引用
收藏
页码：347 / 355
页数：9
相关论文
共 50 条
  • [41] Analysis of Macrophage Activation Markers in an Experimental Model of Cutaneous Leishmaniasis Treated with Photodynamic Therapy Mediated by 5-Aminolevulinic Acid
    Silva, Mona Lisa Fabiana
    Alves, Polyanna Miranda
    Souza, Danila Malheiros
    Silva, Marcos Vinicius
    Santos, Joao Paulo S.
    Paulino, Tony de Paiva
    Rodrigues, Denise Bertulucci
    Rodrigues Jr, Virmondes
    [J]. PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY, 2019, 37 (05) : 298 - 304
  • [42] Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro
    Shi, Lei
    Buchner, Alexander
    Pohla, Heike
    Pongratz, Thomas
    Ruehm, Adrian
    Zimmermann, Wolfgang
    Gederaas, Odrun A.
    Zhang, Linglin
    Wang, Xiuli
    Stepp, Herbert
    Sroka, Ronald
    [J]. JOURNAL OF BIOPHOTONICS, 2019, 12 (10)
  • [43] Aminolevulinic acid derivatives and liposome delivery as strategies for improving 5-aminolevulinic acid-mediated photodynamic therapy
    Casas, A
    Batlle, A
    [J]. CURRENT MEDICINAL CHEMISTRY, 2006, 13 (10) : 1157 - 1168
  • [44] Photodynamic therapy of human glioma spheroids using 5-aminolevulinic acid
    Madsen, SJ
    Sun, CH
    Tromberg, BJ
    Wallace, VP
    Hirschberg, H
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2000, 72 (01) : 128 - 134
  • [45] 5-Aminolevulinic acid-mediated photodynamic therapy for oral cancers and precancers
    Chen, Hsin-Ming
    Yu, Chuan-Hang
    Lin, Hung-Pin
    Cheng, Shih-Jung
    Chiang, Chun-Pin
    [J]. JOURNAL OF DENTAL SCIENCES, 2012, 7 (04) : 307 - 315
  • [46] The current situation of 5-aminolevulinic acid mediated photodynamic therapy in bladder cancer
    Kobza-Mroczkowska, Dagmara
    Khot, M. Ibrahim
    [J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2020, 31
  • [47] 5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Cervical Condylomata Acuminata
    Chen, Mu-Kai
    Luo, Di-Qing
    Zhou, Hui
    Huang, Zeng-Wei
    Zhang, Qin-Fen
    Han, Jian-De
    [J]. PHOTOMEDICINE AND LASER SURGERY, 2011, 29 (05) : 339 - 343
  • [48] Uptake and kinetics of 5-aminolevulinic acid in oral squamous cell carcinoma
    Uekusa, M.
    Omura, K.
    Nakajima, Y.
    Hasegawa, S.
    Harada, H.
    Morita, K. -I.
    Tsuda, H.
    [J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2010, 39 (08) : 802 - 805
  • [49] Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid
    Hillemanns, P
    Untch, M
    Dannecker, C
    Baumgartner, R
    Stepp, H
    Diebold, J
    Weingandt, H
    Pröve, F
    Korell, M
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2000, 85 (05) : 649 - 653
  • [50] Novel potential photodynamic therapy strategy using 5-Aminolevulinic acid for ovarian clear-cell carcinoma
    Teshigawara, Toshiya
    Mizuno, Mika
    Ishii, Takuya
    Kitajima, Yuya
    Utsumi, Fumi
    Sakata, Jun
    Kajiyama, Hiroaki
    Shibata, Kiyosumi
    Ishizuka, Masahiro
    Kikkawa, Fumitaka
    [J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2018, 21 : 121 - 127
12345