Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model

被引：42
|
作者：
Wang, Xiaojie [1 ,2 ]
Shi, Lei [2 ]
Tu, Qingfeng [2 ]
Wang, Hongwei [3 ]
Zhang, Haiyan [2 ]
Wang, Peiru [2 ]
Zhang, Linglin [2 ]
Huang, Zheng [4 ]
Zhao, Feng [5 ]
Luan, Hansen [5 ]
Wang, Xiuli [2 ]
机构：
[1] Anhui Med Univ, Shanghai Skin Dis Clin Coll, Hefei, Peoples R China
[2] Shanghai Skin Dis Hosp, Shanghai 200443, Peoples R China
[3] Fudan Univ, Huadong Hosp, Shanghai 200433, Peoples R China
[4] Fujian Normal Univ, MOE Key Lab OptoElect Sci & Technol Med, Fuzhou, Peoples R China
[5] China State Inst Pharmaceut Ind, Natl Pharmaceut Engn Res Ctr, Shanghai, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2015年 / 10卷
基金：
中国国家自然科学基金;
关键词：
5-aminolevulinic acid (ALA); polylactic-co-glycolic acid (PLGA); nanoparticles (NPs); cutaneous squamous cell carcinoma (SCC); photodynamic therapy (PDT); microneedling; TRANSDERMAL DRUG-DELIVERY; IN-VITRO; MICROFABRICATED MICRONEEDLES; SKIN PENETRATION; VIVO; GUIDELINES; EFFICIENT; CARRIER; CANCER; MEMORY;
D O I：
10.2147/IJN.S71245
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Background: Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC. Materials and methods: Ultraviolet-induced cutaneous SCCs were established in hairless mice. ALA-loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NP-induced protoporphyrin IX fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined. Results: PLGA NPs enhanced protoporphyrin IX production in SCC. ALA PLGA NP-mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC. Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.
引用
收藏
页码：347 / 355
页数：9
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