Quinolactacins A, B and C:: Novel quinolone compounds from Penicillium sp EPF-6 I.: Taxonomy, production, isolation and biological properties

被引：41
|
作者：
Kakinuma, N
Iwai, H
Takahashi, S
Hamano, K
Yanagisawa, T
Nagai, K
Tanaka, K
Suzuki, K
Kirikae, F
Kirikae, T
Nakagawa, A
机构：
[1] Teikyo Univ, Dept Biosci, Utsunomiya, Tochigi 3208551, Japan
[2] Tokyo Univ Agr & Technol, United Grad Sch Agr Sci, Fuchu, Tokyo 1838509, Japan
[3] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Microbiol Labs, Itabashi Ku, Tokyo 1748511, Japan
[4] Japan Res Inst, Int Med Ctr, Shinjuku Ku, Tokyo, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 11期
关键词：
D O I：
10.7164/antibiotics.53.1247
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp, from its morphological characteristics. Quinolactacins were obtained from the culture medium by solvent extraction and chromatographic purification. Compound 1 showed inhibitory activity against turner necrosis factor (TNF) production induced by murine peritoneal macrophages and macrophage-like J774.1 cells stimulated with lipopolysaccharide (LPS).
引用
收藏
页码：1247 / 1251
页数：5
相关论文
共 50 条
  • [31] Fluostatins A and B, new inhibitors of dipeptidyl peptidase III, produced by Streptomyces sp. TA-3391 -: I.: Taxonomy of producing strain, production, isolation, physico-chemical properties and biological properties
    Akiyama, T
    Harada, S
    Kojima, F
    Takahashi, Y
    Imada, C
    Okami, Y
    Muraoka, Y
    Aoyagi, T
    Takeuchi, T
    JOURNAL OF ANTIBIOTICS, 1998, 51 (06): : 553 - 559
  • [32] Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938I. Taxonomy, Fermentation, Isolation and Biological Properties
    Takashi Fukuda
    Yuichi Yamaguchi
    Rokuro Masuma
    Hiroshi Tomoda
    Satoshi Ōmura
    The Journal of Antibiotics, 2005, 58 : 309 - 314
  • [33] Mutactimycin PR, a new anthracycline antibiotic from Saccharothrix sp SA 103 -: I.: Taxonomy, fermentation, isolation and biological activities
    Zitouni, A
    Boudjella, H
    Mathieu, F
    Sabaou, N
    Lebrihi, A
    JOURNAL OF ANTIBIOTICS, 2004, 57 (06): : 367 - 372
  • [34] Formamicin, a novel antifungal antibiotic produced by a strain of Saccharothrix sp. .1. Taxonomy, production, isolation and biological properties
    Igarashi, M
    Kinoshita, N
    Ikeda, T
    Nakagawa, E
    Hamada, M
    Takeuchi, T
    JOURNAL OF ANTIBIOTICS, 1997, 50 (11): : 926 - 931
  • [35] Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora -: I.: Taxonomy, fermentation, isolation and physico-chemical and biological properties
    Kajiura, T
    Furumai, T
    Igarashi, Y
    Hori, H
    Higashi, K
    Ishiyama, T
    Uramoto, M
    Uehara, Y
    Oki, T
    JOURNAL OF ANTIBIOTICS, 1998, 51 (04): : 394 - 401
  • [36] Stachybotrin C and parvisporin, novel neuritogenic compounds .1. Taxonomy, isolation, physico-chemical and biological properties
    Nozawa, Y
    Yamamoto, K
    Ito, M
    Sakai, N
    Mizoue, K
    Mizobe, F
    Hanada, K
    JOURNAL OF ANTIBIOTICS, 1997, 50 (08): : 635 - 640
  • [37] Decatromicins A and B, new antibiotics produced by Actinomadura sp MK73-NF4 -: I.: Taxonomy, isolation, physico-chemical properties and biological activities
    Momose, I
    Iinuma, H
    Kinoshita, N
    Momose, Y
    Kunimoto, S
    Hamada, M
    Takeuchi, T
    JOURNAL OF ANTIBIOTICS, 1999, 52 (09): : 781 - 786
  • [38] GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp -: 1.: Taxonomy, production, isolation, physicochemical properties and biological activities
    Sakai, Y
    Yoshida, T
    Ochiai, K
    Uosaki, Y
    Saitoh, Y
    Tanaka, F
    Akiyama, T
    Akinaga, S
    Mizukami, T
    JOURNAL OF ANTIBIOTICS, 2002, 55 (10): : 855 - 862
  • [39] FR207944, an antifungal antibiotic from Chaetomium sp no. 217 -: I.: Taxonomy, fermentation, and biological properties
    Kobayashi, M
    Kanasaki, R
    Sato, I
    Abe, F
    Nitta, K
    Ezaki, M
    Sakamoto, K
    Hashimoto, M
    Fujie, A
    Hino, M
    Hori, Y
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2005, 69 (03) : 515 - 521
  • [40] Rhodopeptins (Mer-N1033), novel cyclic tetrapeptides with antifungal activity from Rhodococcus sp.: I.: Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
    Chiba, H
    Agematu, H
    Kaneto, R
    Terasawa, T
    Sakai, K
    Dobashi, K
    Yoshioka, T
    JOURNAL OF ANTIBIOTICS, 1999, 52 (08): : 695 - 699
12345