Quinolactacins A, B and C:: Novel quinolone compounds from Penicillium sp EPF-6 I.: Taxonomy, production, isolation and biological properties

被引：41
|
作者：
Kakinuma, N
Iwai, H
Takahashi, S
Hamano, K
Yanagisawa, T
Nagai, K
Tanaka, K
Suzuki, K
Kirikae, F
Kirikae, T
Nakagawa, A
机构：
[1] Teikyo Univ, Dept Biosci, Utsunomiya, Tochigi 3208551, Japan
[2] Tokyo Univ Agr & Technol, United Grad Sch Agr Sci, Fuchu, Tokyo 1838509, Japan
[3] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Microbiol Labs, Itabashi Ku, Tokyo 1748511, Japan
[4] Japan Res Inst, Int Med Ctr, Shinjuku Ku, Tokyo, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 11期
关键词：
D O I：
10.7164/antibiotics.53.1247
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp, from its morphological characteristics. Quinolactacins were obtained from the culture medium by solvent extraction and chromatographic purification. Compound 1 showed inhibitory activity against turner necrosis factor (TNF) production induced by murine peritoneal macrophages and macrophage-like J774.1 cells stimulated with lipopolysaccharide (LPS).
引用
收藏
页码：1247 / 1251
页数：5
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