Disease-associated functions of IL-33: the new kid in the IL-1 family

被引：831

作者：

Liew, Foo Y. ^{[1
]}

Pitman, Nick I. ^{[1
]}

McInnes, Iain B. ^{[1
]}

机构：

[1] Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow Biomed Res Ctr, Glasgow G12 8TA, Lanark, Scotland

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 02期

基金：

英国医学研究理事会;

关键词：

RECEPTOR ACCESSORY PROTEIN; IL-1-LIKE CYTOKINE IL-33; ST2; GENE-PRODUCT; HUMAN MAST-CELLS; INTERLEUKIN-1; RECEPTOR; AIRWAY INFLAMMATION; TH2; CELLS; IN-VIVO; SUBARACHNOID HEMORRHAGE; MYOCARDIAL-INFARCTION;

D O I：

10.1038/nri2692

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T(H)2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T(H)2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding T(H)2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.

引用

页码：103 / 110

页数：8

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