Disease-associated functions of IL-33: the new kid in the IL-1 family

被引：831
|
作者：
Liew, Foo Y. [1 ]
Pitman, Nick I. [1 ]
McInnes, Iain B. [1 ]
机构：
[1] Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow Biomed Res Ctr, Glasgow G12 8TA, Lanark, Scotland
来源：
NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 02期
基金：
英国医学研究理事会;
关键词：
RECEPTOR ACCESSORY PROTEIN; IL-1-LIKE CYTOKINE IL-33; ST2; GENE-PRODUCT; HUMAN MAST-CELLS; INTERLEUKIN-1; RECEPTOR; AIRWAY INFLAMMATION; TH2; CELLS; IN-VIVO; SUBARACHNOID HEMORRHAGE; MYOCARDIAL-INFARCTION;
D O I：
10.1038/nri2692
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T(H)2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T(H)2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding T(H)2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.
引用
收藏
页码：103 / 110
页数：8
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