IL-33, a new cytokine of the IL-1 family involved in allergic inflammation

被引：0
|
作者：
Girard, J. -P. [1 ,2 ]
机构：
[1] CNRS, IPBS, F-31077 Toulouse, France
[2] Univ Toulouse, IPBS, UPS, F-31077 Toulouse, France
来源：
REVUE FRANCAISE D ALLERGOLOGIE | 2010年 / 50卷 / 03期
关键词：
Cytokines; IL-1; IL-33; ST2; receptor; Inflammation; Allergy; IN-VIVO; CHROMATIN;
D O I：
10.1016/j.reval.2010.02.003
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Cytokines of the IL-1 family play a very important role in immunity and inflammation, and thus represent promising therapeutic targets for many chronic inflammatory diseases Indeed. IL-1 inhibitors are currently used in the treatment of rheumatoid arthritis IL-33, the most recent addition to the IL-1 family. has structural homologies with IL-1 and binds to the ST2 receptor (IL-1R4), a member of the IL-1 receptor superfamily expressed by inflammatory cells involved in allergy (Th2 lymphocytes, mast cells. basophils. eosmophils, iNKT cells) Because of its capacity to induce allergic-type inflammatory responses. IL-33 could be a major factor in asthma and other allergic diseases (atopic dermatitis, allergic rhinitis) (C) 2010 Elsevier Masson SAS All rights reserved
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收藏
页码：92 / 93
页数：2
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