Checkpoint inhibition: NK cells enter the scene

被引：18
|
作者：
Stojanovic, Ana [1 ]
Cerwenka, Adelheid [1 ,2 ]
机构：
[1] Heidelberg Univ, Med Fac Mannheim, Ctr Biomed & Med Technol, Mannheim, Germany
[2] Heidelberg Univ, Med Fac Mannheim, European Ctr Angiosci, Mannheim, Germany
来源：
NATURE IMMUNOLOGY | 2018年 / 19卷 / 07期
关键词：
CANCER-IMMUNOTHERAPY; TIGIT;
D O I：
10.1038/s41590-018-0142-y
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tumor-associated natural killer cells have elevated expression of the checkpoint inhibitory receptor TIGIT. Monoclonal antibody-mediated blockade targeting TIGIT unleashes the anti-tumor activity of both natural killer cells and T cells in preclinical mouse models and efficiently delays tumor growth.
引用
收藏
页码：650 / 652
页数：4
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