Checkpoint inhibition: NK cells enter the scene

被引：18
|
作者：
Stojanovic, Ana [1 ]
Cerwenka, Adelheid [1 ,2 ]
机构：
[1] Heidelberg Univ, Med Fac Mannheim, Ctr Biomed & Med Technol, Mannheim, Germany
[2] Heidelberg Univ, Med Fac Mannheim, European Ctr Angiosci, Mannheim, Germany
来源：
NATURE IMMUNOLOGY | 2018年 / 19卷 / 07期
关键词：
CANCER-IMMUNOTHERAPY; TIGIT;
D O I：
10.1038/s41590-018-0142-y
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tumor-associated natural killer cells have elevated expression of the checkpoint inhibitory receptor TIGIT. Monoclonal antibody-mediated blockade targeting TIGIT unleashes the anti-tumor activity of both natural killer cells and T cells in preclinical mouse models and efficiently delays tumor growth.
引用
收藏
页码：650 / 652
页数：4
相关论文
共 50 条
  • [41] T cells pass on the baton during checkpoint inhibition
    Ulrike Harjes
    [J]. Nature Reviews Cancer, 2019, 19 : 546 - 546
  • [42] The scientific process: new forces attempt to enter the scene
    Kinne, O
    [J]. AQUATIC MICROBIAL ECOLOGY, 2003, 32 (02) : 105 - 105
  • [43] Variable receptors controlling activation and inhibition of NK cells
    McQueen, KL
    Parham, P
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (05) : 615 - 621
  • [44] The scientific process: new forces attempt to enter the scene
    Kinne, O
    [J]. CLIMATE RESEARCH, 2003, 24 (01) : 1 - 1
  • [45] The scientific process: new forces attempt to enter the scene
    Kinne, O
    [J]. MARINE ECOLOGY PROGRESS SERIES, 2003, 254 : 1 - 1
  • [46] Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis
    Ortner, Daniela
    Tripp, Christoph H.
    Komenda, Kerstin
    Dubrac, Sandrine
    Zelger, Bernhard
    Hermann, Martin
    Doppler, Wolfgang
    Tymoszuk, Piotr Z.
    Boon, Louis
    Clausen, Bjoern E.
    Stoitzner, Patrizia
    [J]. ONCOIMMUNOLOGY, 2017, 6 (02):
  • [47] Enter a scene-stealing crocdile (Iris Wilkinson)
    Lloyd-Jenkins, D
    [J]. LANDFALL, 2003, (206): : 184 - 187
  • [48] Ovarian tumor-induced CISH expression is an immune checkpoint for NK cells
    Stasik, Amy K.
    Yellapa, Aparna
    Bitterman, Pincas
    Sharma, Sameer
    Basu, Sanjib
    Barua, Animesh
    [J]. CANCER RESEARCH, 2018, 78 (13)
  • [49] Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition
    Arnould, Stephanie
    Rodier, Genevieve
    Matar, Gisele
    Vincent, Charles
    Pirot, Nelly
    Delorme, Yoann
    Berthet, Charlene
    Buscail, Yoan
    Noel, Jean Yohan
    Lachambre, Simon
    Jarlier, Marta
    Bernex, Florence
    Delpech, Helene
    Vidalain, Pierre Olivier
    Janin, Yves L.
    Theillet, Charles
    Sardet, Claude
    [J]. ONCOTARGET, 2017, 8 (56) : 95206 - 95222
  • [50] Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma
    Carlsten, Mattias
    Korde, Neha
    Kotecha, Ritesh
    Reger, Robert
    Bor, Simona
    Kazandjian, Dickran
    Landgren, Ola
    Childs, Richard W.
    [J]. CLINICAL CANCER RESEARCH, 2016, 22 (21) : 5211 - 5222
12345