Mechanisms of NK cell activation: CD4+ T cells enter the scene

被引：0
|
作者：
Franck Bihl
Claire Germain
Carmelo Luci
Veronique M. Braud
机构：
[1] Centre National de la Recherche Scientifique/Université de Nice-Sophia Antipolis,Institut de Pharmacologie Moléculaire et Cellulaire
[2] UMR6097,Faculté de Médecine Pasteur
[3] Inserm,undefined
[4] U634,undefined
来源：
Cellular and Molecular Life Sciences | 2011年 / 68卷
关键词：
Natural killer cells; Antigen-presenting cells; CD4; T cells; NK receptors; IL-12; IL-2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Natural killer (NK) cells are innate lymphocytes involved in immunosurveillance through their cytotoxic activity and their capacity to secrete inflammatory cytokines. NK cell activation is necessary to initiate effector functions and results from a complex series of molecular and cellular events. We review here the signals that trigger NK cells and discuss recent findings showing that, besides antigen-presenting cells, T cells can play a central role in the initiation of NK cell activation in lymph nodes.
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页码：3457 / 3467
页数：10
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