Cutaneous and Gastrointestinal Leukocytoclastic Vasculitis Induced by Palbociclib in a Metastatic Breast Cancer Patient: A Case Report

被引：8

作者：

Guillemois, Sylvere ^{[1
]}

Patsouris, Anne ^{[1
]}

Peyraga, Guillaume ^{[2
]}

Chassain, Kevin ^{[3
]}

Le Corre, Yannick ^{[3
]}

Campone, Mario ^{[1
]}

Augereau, Paule ^{[1
]}

机构：

[1] Ctr Paul Papin, Med Oncol Dept, Inst Cancerol Ouest, Angers, France

[2] Ctr Paul Papin, Radiat Therapy Dept, Inst Cancerol Ouest, Angers, France

[3] Univ Hosp Angers, Dermatol Dept, Angers, France

来源：

CLINICAL BREAST CANCER | 2018年 / 18卷 / 05期

关键词：

Cyclin-dependent kinase 4/6 inhibitor; Drug-induced vasculitis; Faslodex; Fulvestrant; Ibrance; Vasculitis treatment; RANDOMIZED CONTROLLED-TRIAL; THERAPY; LETROZOLE;

D O I：

10.1016/j.clbc.2018.07.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The efficacy and safety of palbociclib, a cyclindependent kinase 4/6 inhibitor, used in combination with fulvestrant was assessed in women with advanced breast cancer (ABC) whose disease had progressed during previous endocrine therapy, with a significant improvement of progression-free survival and good health-related quality of life. We report a case of an 80-year-old patient with ABC who presented a cutaneous and gastrointestinal vasculitis during treatment with palbociclib and fulvestrant. The skin biopsy was consistent with a leukocytoclastic vasculitis with immunoglobulin A deposits in dermal blood vessels. The symptoms disappeared with the arrest of palbociclib and fulvestrant treatment and a high dose corticotherapy. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：E755 / E758

页数：4

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