Nutritional Influences on Epigenetic Programming Asthma, Allergy, and Obesity

被引：17
|
作者：
Palmer, Debra J. [1 ]
Huang, Rae-Chi [2 ]
Craig, Jeffrey M. [3 ,4 ]
Prescott, Susan L. [1 ,2 ]
机构：
[1] Univ Western Australia M561, Sch Paediat & Child Hlth, Subiaco, WA 6008, Australia
[2] Univ Western Australia, Telethon KIDS Inst, Subiaco, WA 6008, Australia
[3] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia
[4] Royal Childrens Hosp, Murdoch Childrens Res Inst, Early Life Epigenet Grp, Parkville, Vic 3052, Australia
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2014年 / 34卷 / 04期
关键词：
Nutrition; Early life; Epigenetic regulation; Asthma; Allergy; Obesity; FISH-OIL SUPPLEMENTATION; FATTY-ACID SUPPLEMENTATION; DNA METHYLATION; FOLIC-ACID; GUT MICROBIOTA; HIGH-RISK; DEVELOPMENTAL ORIGINS; PROMOTER METHYLATION; IMMUNE-RESPONSES; CHILDHOOD ASTHMA;
D O I：
10.1016/j.iac.2014.07.003
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Observational studies show consistent links between early-life nutritional exposures as important risk factors for the development of asthma, allergy, and obesity. Reliance on increasing use of dietary supplementation and fortification (eg, with folate) to compensate for increased consumption of processed foods is also influencing immune and metabolic outcomes. Epigenetics is providing substantial advances in understanding how early-life nutritional exposures can effect disease development. This article summarizes current evidence linking the influence of early-life nutritional exposures on epigenetic regulation with a focus on the disease outcomes of asthma, allergy, and obesity.
引用
收藏
页码：825 / +
页数：14
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