Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus

被引：91

作者：

Ruchat, Stephanie-May ^{[1
,2
,3
]}

Hivert, Marie-France ^{[4
]}

Bouchard, Luigi ^{[1
,2
,3
]}

机构：

[1] Univ Sherbrooke, Dept Biochem, Sherbrooke, PQ J1K 2R1, Canada

[2] Chicoutimi Hosp, ECOGENE 21, Saguenay, PQ, Canada

[3] Chicoutimi Hosp, Lipid Clin, Saguenay, PQ, Canada

[4] Univ Sherbrooke, Dept Med, Sherbrooke, PQ J1K 2R1, Canada

来源：

NUTRITION REVIEWS | 2013年 / 71卷

关键词：

altered intrauterine environment; diabetes; epigenetic modifications; fetal metabolic programming; gestational diabetes; obesity; DNA METHYLATION; BIRTH-WEIGHT; INTRAUTERINE EXPOSURE; GENE-EXPRESSION; GLUCOCORTICOID-RECEPTOR; PROMOTER METHYLATION; CARDIOVASCULAR RISK; ASSOCIATION; ADIPONECTIN; LEPTIN;

D O I：

10.1111/nure.12057

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

It is now well accepted that offspring exposed to maternal undernutrition, obesity, or gestational diabetes mellitus have an increased risk for chronic diseases later in life, supporting the theory of the early origins of chronic diseases. However, the molecular mechanisms through which the exposure to an altered in utero environment translates into the development of chronic diseases are not yet well understood. Recently reported promising results help to resolve this issue. They suggest that epigenetic modifications are a potential mechanism for fetal metabolic programming. This review provides an overview of the relationship between the exposure to an altered intrauterine environment and fetal metabolic programming, focusing on gestational diabetes mellitus and epigenetic variations at adipokine candidate genes. (C) 2013 International Life Sciences Institute

引用

页码：S88 / S94

页数：7

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