Total Synthesis of Auripyrones A and B and Determination of the Absolute Configuration of Auripyrone B

被引:19
|
作者
Hayakawa, Ichiro [1 ]
Takemura, Takuma [1 ]
Fukasawa, Emi [1 ]
Ebihara, Yuta [1 ]
Sato, Natsuki [1 ]
Nakamura, Takayasu [1 ]
Suenaga, Kiyotake [1 ]
Kigoshi, Hideo [1 ]
机构
[1] Univ Tsukuba, Dept Chem, Grad Sch Pure & Appl Sci, Tsukuba, Ibaraki 3058571, Japan
关键词
aldol reactions; auripyrones; diastereoselectiyity; natural products; total synthesis; NATURAL-PRODUCTS; ALDOL REACTIONS; METABOLITES;
D O I
10.1002/anie.200906662
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) The winner takes it aldol: The total synthesis of auripyrones A and B was achieved using a diastereoselective aldol-type reaction with 2, 6-diethyl-3, 5-dimethyl-4-pyrone as a key step. The stereostructure and absolute configura-tion of auripyrone B has also been determined. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:2401 / 2405
页数:5
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