Comparative genomics and understanding of microbial biology

被引：45
|
作者：
Fraser, CM [1 ]
Eisen, J [1 ]
Fleischmann, RD [1 ]
Ketchum, KA [1 ]
Peterson, S [1 ]
机构：
[1] Inst Genom Res, Rockville, MD 20850 USA
来源：
EMERGING INFECTIOUS DISEASES | 2000年 / 6卷 / 05期
关键词：
D O I：
10.3201/eid0605.000510
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The sequences of close to 30 microbial genomes have been completed during the past 5 years, and the sequences of more than 100 genomes should be completed in the next 2 to 4 years. Soon, completed microbial genome sequences will represent a collection of >200,000 predicted coding sequences. While analysis of a single genome provides tremendous biological insights on any given organism, comparative analysis of multiple genomes provides substantially more information on the physiology and evolution of microbial species and expands our ability to better assign putative function to predicted coding sequences.
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页码：505 / 512
页数：8
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