Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis

被引：141
|
作者：
Centonze, D.
Koch, G.
Versace, V.
Mori, F.
Rossi, S.
Brusa, L.
Grossi, K.
Torelli, F.
Prosperetti, C.
Cervellino, A.
Marfia, G. A.
Stanzione, P.
Marciani, M. G.
Boffa, L.
Bernardi, G.
机构：
[1] Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy
[2] IRCCS, Fdn Santa Lucia, Rome, Italy
来源：
NEUROLOGY | 2007年 / 68卷 / 13期
关键词：
D O I：
10.1212/01.wnl.0000257818.16952.62
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. Methods: We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing remitting multiple sclerosis and lower limb spasticity. Results: A single session of 1 Hz rTMS over the leg primary motor cortex increased H/M amplitude ratio of the soleus H reflex, a reliable neurophysiologic measure of stretch reflex. Five hertz rTMS decreased H/M amplitude ratio of the soleus H reflex and increased corticospinal excitability. Single sessions did not induce any effect on spasticity. A significant improvement of lower limb spasticity was observed when rTMS applications were repeated during a 2-week period. Clinical improvement was long-lasting (at least 7 days after the end of treatment) when the patients underwent 5 Hz rTMS treatment during a 2-week protocol. No effect was obtained after a 2-week sham stimulation. Conclusions: Repetitive transcranial magnetic stimulation may improve spasticity in multiple sclerosis.
引用
收藏
页码：1045 / 1050
页数：6
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