Direct demonstration of the effects of repetitive transcranial magnetic stimulation on the excitability of the human motor cortex

被引：100
|
作者：
Di Lazzaro, V
Oliviero, A
Berardelli, A
Mazzone, P
Insola, A
Pilato, F
Saturno, E
Dileone, M
Tonali, PA
Rothwell, JC
机构：
[1] Univ Cattolica Sacro Cuore, Neurol Inst, I-00168 Rome, Italy
[2] Univ Roma La Sapienza, Dipartimento Sci Neurol, Ist Neurol Neuromed, IRCCS, Rome, Italy
[3] Neurochirurg CTO, I-00145 Rome, Italy
[4] Neurofisiol CTO, I-00145 Rome, Italy
[5] IRCCS Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy
[6] Inst Neurol, Sobell Dept Neurophysiol, London WC1N 3BG, England
[7] UCL Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England
来源：
EXPERIMENTAL BRAIN RESEARCH | 2002年 / 144卷 / 04期
关键词：
transcranial magnetic stimulation; plasticity; motor cortex; rTMS;
D O I：
10.1007/s00221-002-1106-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of repetitive transcranial magnetic stimulation (rTMS; 20 stimuli at 5 Hz at 120% resting motor threshold intensity using a biphasic stimulus pulse) on the excitability of human motor cortex were investigated in two patients who had an electrode implanted into the cervical epidural space. The corticospinal D wave increased in amplitude with successive stimuli, and reached a maximum after three or five pulses. At this stage, the amplitude of the I waves was unchanged, but after a further 10 stimuli an additional I wave was recruited. Both effects were still evident 2 min after the end of the rTMS. The effects are compatible with a short-term increase in cortical excitability during suprathreshold rTMS.
引用
收藏
页码：549 / 553
页数：5
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