Autoimmune Valvular Carditis

被引：13
|
作者：
Breed, Elise R. [1 ]
Binstadt, Bryce A. [1 ]
机构：
[1] Univ Minnesota, Div Pediat Rheumatol, Dept Pediat, Ctr Immunol, Minneapolis, MN 55414 USA
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2015年 / 15卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Valvular carditis; Endocarditis; Autoimmune; Rheumatic; T cell; Macrophage; INTERLEUKIN-1 RECEPTOR ANTAGONIST; RHEUMATIC HEART-DISEASE; STREPTOCOCCAL-M-PROTEIN; SYSTEMIC-LUPUS-ERYTHEMATOSUS; LIBMAN-SACKS ENDOCARDITIS; REGULATORY T-CELLS; ANTIPHOSPHOLIPID SYNDROME; AUTOINFLAMMATORY DISEASE; MONOCLONAL-ANTIBODIES; LEWIS RATS;
D O I：
10.1007/s11882-014-0491-z
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Autoimmune carditis is associated with many human rheumatic conditions, including rheumatic fever, systemic lupus erythematosus, and rheumatoid arthritis. The immune mechanisms that mediate the cardiovascular pathology connected to these diseases are poorly defined. Several animal models are used to recapitulate human pathophysiology in order to better characterize the immunopathogenic mechanisms driving autoimmune endocardial inflammation. These animal models point toward common mechanisms mediating autoimmune endocarditis; in particular, CD4+ T cells and proinflammatory macrophages play critical roles in directing the disease process. The goals of this review are to discuss the prevailing animal models of autoimmune endocarditis and their underlying immunologic mechanisms and to provide insight regarding potential therapeutic targets in humans.
引用
收藏
页码：1 / 7
页数：7
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