Autoimmune Valvular Carditis

被引：13

作者：

Breed, Elise R. ^{[1
]}

Binstadt, Bryce A. ^{[1
]}

机构：

[1] Univ Minnesota, Div Pediat Rheumatol, Dept Pediat, Ctr Immunol, Minneapolis, MN 55414 USA

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2015年 / 15卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Valvular carditis; Endocarditis; Autoimmune; Rheumatic; T cell; Macrophage; INTERLEUKIN-1 RECEPTOR ANTAGONIST; RHEUMATIC HEART-DISEASE; STREPTOCOCCAL-M-PROTEIN; SYSTEMIC-LUPUS-ERYTHEMATOSUS; LIBMAN-SACKS ENDOCARDITIS; REGULATORY T-CELLS; ANTIPHOSPHOLIPID SYNDROME; AUTOINFLAMMATORY DISEASE; MONOCLONAL-ANTIBODIES; LEWIS RATS;

D O I：

10.1007/s11882-014-0491-z

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune carditis is associated with many human rheumatic conditions, including rheumatic fever, systemic lupus erythematosus, and rheumatoid arthritis. The immune mechanisms that mediate the cardiovascular pathology connected to these diseases are poorly defined. Several animal models are used to recapitulate human pathophysiology in order to better characterize the immunopathogenic mechanisms driving autoimmune endocardial inflammation. These animal models point toward common mechanisms mediating autoimmune endocarditis; in particular, CD4+ T cells and proinflammatory macrophages play critical roles in directing the disease process. The goals of this review are to discuss the prevailing animal models of autoimmune endocarditis and their underlying immunologic mechanisms and to provide insight regarding potential therapeutic targets in humans.

引用

页码：1 / 7

页数：7

共 50 条

[21] ABERRANT EXPRESSION OF HLA-DR ANTIGEN ON VALVULAR FIBROBLASTS FROM PATIENTS WITH ACTIVE RHEUMATIC CARDITIS
AMOILS, B
MORRISON, RC
WADEE, AA
MARCUS, R
NININ, D
KING, P
SARELI, P
LEVIN, S
RABSON, AR
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1986, 66 (01): : 88 - 94
[22] Understanding valvular heart disease in patients with systemic autoimmune diseases
Maksimowicz-McKinnon, K
Mandell, BF
CLEVELAND CLINIC JOURNAL OF MEDICINE, 2004, 71 (11) : 881 - 885
[23] Induction of autoimmune valvular heart disease by recombinant streptococcal M protein
Quinn, A
Kosanke, S
Fischetti, VA
Factor, SM
Cunningham, MW
INFECTION AND IMMUNITY, 2001, 69 (06) : 4072 - 4078
[24] The neutrophil-to-lymphocyte ratio and mean platelet volume can be associated with severity of valvular involvement in patients with acute rheumatic carditis
Celik, Serkan F.
Celik, Elif
CARDIOVASCULAR JOURNAL OF AFRICA, 2018, 29 (05) : 296 - 300
[25] ECHOVIRUSES AND CARDITIS
RAINFORD, DJ
LEWES, D
LANCET, 1970, 1 (7656): : 1114 - &
[26] RHEUMATIC CARDITIS
BOLTE, HD
INTERNIST, 1975, 16 (11): : 501 - 507
[27] RHEUMATOID CARDITIS
SCHWARTZ, S
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1967, 201 (07) : 556 - +
[28] RHEUMATIC CARDITIS
THORNTON, CE
BRITISH MEDICAL JOURNAL, 1953, 1 (4805): : 334 - 334
[29] YERSINIA CARDITIS
LAITINEN, O
LEIRISALO, M
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1975, 4 : 602 - 602
[30] ECHOVIRUSES AND CARDITIS
LEWES, D
RAINFORD, DJ
LANCET, 1970, 1 (7645): : 520 - &

← 1 2 3 4 5 →