Synthesis of some novel 2,3,4,8,9-pentahydro-7-(4-haloaryl)pyrazolo[5,1-e]benzo[1,5]oxazocines and 2,3(erythro),7,8-tetrahydro-2-aryl-3-(4-fluoro-3-methylbenzoyl)-6-(4-haloaryl)pyrazolo[5,1-d]benzo[1,4]oxazepines via solid-liquid PTC

被引：8

作者：

Pathak, Vijai N. ^{[1
]}

Gupta, Ragini

Tiwari, Ranjana

Gupta, Rekha

Sareen, Vineeta

Varshney, Bindu

机构：

[1] Univ Rajasthan, Ctr Adv Studies, Dept Chem, Jaipur 302004, Rajasthan, India

[2] Malaviya Natl Inst Technol, Dept Chem, Jaipur, Rajasthan, India

[3] Univ Rajasthan, Ctr Adv Studies, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 4-6期

关键词：

1,4-benzoxazepines; 1,5-benzoxazocines; dihaloalkane; heterocyclization; pyrazoles; regioselective synthesis; solid-liquid phase-transfer catalysis;

D O I：

10.1080/00397910601163927

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this communication, a simple and straightforward procedure for the heterocyclization of 1H-4,5-dihydro-3-(4-haloaryl)-5-substituted phenylpyrazoles (4) with 1-bromo-3-chloropropane and 2,3-dibromo-1-(4-fluoro-3-methylphenyl)-3-phenylpropanone affording 2,3,4,8,9-pentahydro-7-(4-haloaryl)pyrazolo[5,1-e]benzo[1,5] oxazocines 5 and regioselective synthesis of 2,3(erythro),7,8-tetrahydro-2aryl-3-(4-fluoro-3-methylbenzoyl)-6-(4-halophenyl)pyrazolo[5,1-d]benzo[1,4]oxa- zepines 6, respectively, via solid-liquid PTC is reported. All the synthesized compounds have been characterized on the basis of their spectral studies (IR, PMR, and MS) and analytical data.

引用

页码：977 / 984

页数：8

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