Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

被引：0

作者：

Yamamoto, Masahiko

Zhu, Changjin

Yi, Lui

Rong, Zheng

Miura, Yoshie

Izumi, Minoru

Nakajima, Shuhei

Tanamoto, Ken-ichi

Shimizu, Sakayu

Baba, Naomichi

机构：

[1] Okayama Univ, Grad Sch Nat Sci & Technol, Dept Biofunct Chem, Okayama 7008530, Japan

[2] Beijing Inst Technol, Sch Chem Engn & Environm, Beijing 100081, Peoples R China

[3] Natl Inst Hlth Sci, Div Food Addit, Setagaya Ku, Tokyo 1588501, Japan

[4] Kyoto Univ, Grad Sch Agr, Dept Appl Biosci, Sakyo Ku, Kyoto 6068502, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 04期

关键词：

pyrrole polyamide; lipid; phospholipid; cancer cell; human immunodeficiency virus (HIV)-II;

D O I：

10.1271/bbb.60650

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

引用

页码：1078 / 1082

页数：5

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