Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

被引：0
|
作者：
Yamamoto, Masahiko
Zhu, Changjin
Yi, Lui
Rong, Zheng
Miura, Yoshie
Izumi, Minoru
Nakajima, Shuhei
Tanamoto, Ken-ichi
Shimizu, Sakayu
Baba, Naomichi
机构：
[1] Okayama Univ, Grad Sch Nat Sci & Technol, Dept Biofunct Chem, Okayama 7008530, Japan
[2] Beijing Inst Technol, Sch Chem Engn & Environm, Beijing 100081, Peoples R China
[3] Natl Inst Hlth Sci, Div Food Addit, Setagaya Ku, Tokyo 1588501, Japan
[4] Kyoto Univ, Grad Sch Agr, Dept Appl Biosci, Sakyo Ku, Kyoto 6068502, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 04期
关键词：
pyrrole polyamide; lipid; phospholipid; cancer cell; human immunodeficiency virus (HIV)-II;
D O I：
10.1271/bbb.60650
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.
引用
收藏
页码：1078 / 1082
页数：5
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