Enantioselective creation of quaternary carbon centers through addition-elimination reaction: Asymmetric nitroolefination of 3-substituted 2-oxindoles

被引：40

作者：

Fuji, K ^{[1
]}

Kawabata, T

Ohmori, T

Shang, MH

Node, M

机构：

[1] Kyoto Univ, Inst Chem Res, Uji 611, Japan

[2] Kyoto Pharmaceut Univ, Kyoto 607, Japan

来源：

HETEROCYCLES | 1998年 / 47卷 / 02期

关键词：

D O I：

10.3987/COM-97-S(N)107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nitroolefination of 3-substituted 2-oxindoles with nitroenamine (5) afforded the corresponding products having quaternary carbon centers with high ee in good yield. Application of this method to concise syntheses of (-)-esermethole (24) and (-)-pseudophrynaminol (28) is described.

引用

页码：951 / 964

页数：14

共 39 条

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