Molecular docking analysis of antimicrobial peptides with the CXCL1 protein target for colorectal cancer

被引:1
|
作者
Kumar, Praveen Kumar [1 ]
Piramanayagam, Shanmughavel [1 ]
机构
[1] Bharathiar Univ, Dept Bioinformat, Computat Biol Lab, Coimbatore 641046, Tamil Nadu, India
关键词
Antimicrobial peptides; colorectal cancer; Peptide docking; Schrodinger;
D O I
10.6026/97320630017369
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Antimicrobial peptides (AMPs) play a prominent role in drug discovery due to the rapid increase in drug resistant infections. Hence, we report the molecular docking analysis of antimicrobial peptides MREEKKERKRD and MVQGAKRGGRLHRV with the target protein CXCL1 in the context of colorectal cancer for further consideration in drug discovery.
引用
收藏
页码:369 / 376
页数:8
相关论文
共 50 条
  • [21] ADIPONECTIN PROMOTES ANGIOGENESIS VIA CXCL1 IN OVARIAN CANCER
    Ouh, Y. T.
    Cho, H. W.
    Chang, I.
    Jin-Hwa, H.
    Lee, J. K.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2018, 28 : 199 - 199
  • [22] Molecular docking studies of angiogenesis target protein HIF-1α and genistein in breast cancer
    Mukund, Vidya
    Saddala, Madhu Sudhana
    Farran, Batoul
    Mannavarapu, Mastan
    Alam, Afroz
    Nagaraj, Ganji Purnachandra
    GENE, 2019, 701 : 169 - 172
  • [23] A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
    Acharyya, Swarnali
    Oskarsson, Thordur
    Vanharanta, Sakari
    Malladi, Srinivas
    Kim, Juliet
    Morris, Patrick G.
    Manova-Todorova, Katia
    Leversha, Margaret
    Hogg, Nancy
    Seshan, Venkatraman E.
    Norton, Larry
    Brogi, Edi
    Massague, Joan
    CELL, 2012, 150 (01) : 165 - 178
  • [24] Molecular Basis of Glycosaminoglycan Heparin Binding to the Chemokine CXCL1 Dimer
    Poluri, Krishna Mohan
    Joseph, Prem Raj B.
    Sawant, Kirti V.
    Rajarathnam, Krishna
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (35) : 25143 - 25153
  • [25] EMT-mediated regulation of CXCL1/5 for resistance to anti-EGFR therapy in colorectal cancer
    Park, Ye-Lim
    Kim, Hwang-Phill
    Ock, Chan-Young
    Min, Dong-Wook
    Kang, Jun Kyu
    Lim, Yoo Joo
    Song, Sang-Hyun
    Han, Sae-Won
    Kim, Tae-You
    ONCOGENE, 2022, 41 (14) : 2026 - 2038
  • [26] CXCL1 promotes immune escape in colorectal cancer by autophagy-mediated MHC-I degradation
    Kong, Jianqiao
    Xu, Song
    Zhang, Peng
    Zhao, Yun
    HUMAN IMMUNOLOGY, 2023, 84 (12)
  • [27] EMT-mediated regulation of CXCL1/5 for resistance to anti-EGFR therapy in colorectal cancer
    Ye-Lim Park
    Hwang-Phill Kim
    Chan-Young Ock
    Dong-Wook Min
    Jun Kyu Kang
    Yoo Joo Lim
    Sang-Hyun Song
    Sae-Won Han
    Tae-You Kim
    Oncogene, 2022, 41 : 2026 - 2038
  • [28] TGFβ1 induces CXCL1 to promote stemness features in lung cancer
    Peng, Ta-Jung
    Wu, Yi-Ching
    Tang, Shye-Jye
    Sun, Guang-Huan
    Sun, Kuang-Hui
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2023, 248 (23) : 2249 - 2261
  • [29] The Chemokine Cxcl1 Is a Novel Target Gene of Parathyroid Hormone (PTH)/PTH-Related Protein in Committed Osteoblasts
    Onan, Doene
    Allan, Elizabeth H.
    Quinn, Julian M. W.
    Gooi, Jonathan H.
    Pompolo, Sueli
    Sims, Natalie A.
    Gillespie, Matthew T.
    Martin, T. John
    ENDOCRINOLOGY, 2009, 150 (05) : 2244 - 2253
  • [30] Combining molecular docking and molecular dynamics simulations to propose novel antimicrobial peptides
    Buimaga-Iarinca, L.
    Farcas, A.
    Janosi, L.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2019, 48 : S198 - S198