Novel Tween® 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma

被引：20

作者：

Masotti, Andrea ^{[1
]}

Vicennati, Paola ^{[2
]}

Alisi, Anna ^{[3
]}

Marianecci, Carlotta ^{[4
]}

Rinaldi, Federica ^{[4
]}

Carafa, Maria ^{[4
]}

Ortaggi, Giancarlo ^{[2
]}

机构：

[1] IRCCS Childrens Hosp Bambino Gesu, Gene Express Microarrays Lab, I-00165 Rome, Italy

[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[3] IRCCS Childrens Hosp Bambino Gesu, Liver Unit, I-00165 Rome, Italy

[4] Univ Roma La Sapienza, Dept Chim & Tecnol Farmaco, Fac Pharm, I-00185 Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 10期

关键词：

Tween (R) 20; pH-sensitive vesicles; Drug delivery systems; Hepatoblastoma; NON-PHOSPHOLIPID VESICLE; SURFACTANT VESICLES; LIVER-TUMORS; LIPOSOMES; POLYSORBATE-20; NIOSOMES;

D O I：

10.1016/j.bmcl.2010.04.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe the synthesis, the physicochemical characterization and the biological evaluation of three novel pH-sensitive systems prepared derivatizing polysorbate 20 (Tween (R) 20) with glycine, N-methylglycine and N,N-dimethyl-glycine (TW20-GLY, TW20-MMG and TW20-DMG). These derivatives form pH-sensitive vesicles and translocate small molecules into cells. The reported systems are efficient drug delivery systems for human hepatoblastoma cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3021 / 3025

页数：5

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