Novel Tween® 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma

被引：20

作者：

Masotti, Andrea ^{[1
]}

Vicennati, Paola ^{[2
]}

Alisi, Anna ^{[3
]}

Marianecci, Carlotta ^{[4
]}

Rinaldi, Federica ^{[4
]}

Carafa, Maria ^{[4
]}

Ortaggi, Giancarlo ^{[2
]}

机构：

[1] IRCCS Childrens Hosp Bambino Gesu, Gene Express Microarrays Lab, I-00165 Rome, Italy

[2] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

[3] IRCCS Childrens Hosp Bambino Gesu, Liver Unit, I-00165 Rome, Italy

[4] Univ Roma La Sapienza, Dept Chim & Tecnol Farmaco, Fac Pharm, I-00185 Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 10期

关键词：

Tween (R) 20; pH-sensitive vesicles; Drug delivery systems; Hepatoblastoma; NON-PHOSPHOLIPID VESICLE; SURFACTANT VESICLES; LIVER-TUMORS; LIPOSOMES; POLYSORBATE-20; NIOSOMES;

D O I：

10.1016/j.bmcl.2010.04.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe the synthesis, the physicochemical characterization and the biological evaluation of three novel pH-sensitive systems prepared derivatizing polysorbate 20 (Tween (R) 20) with glycine, N-methylglycine and N,N-dimethyl-glycine (TW20-GLY, TW20-MMG and TW20-DMG). These derivatives form pH-sensitive vesicles and translocate small molecules into cells. The reported systems are efficient drug delivery systems for human hepatoblastoma cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3021 / 3025

页数：5

共 50 条

[31] Intracellular pH-Sensitive PEG-block-Acetalated-Dextrans as Efficient Drug Delivery Platforms
Zhang, Zhe
Chen, Xiaofei
Chen, Li
Yu, Shuangjiang
Cao, Yue
He, Chaoliang
Chen, Xuesi
ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (21) : 10760 - 10766
[32] A Novel Ketal-Based Chitosan as Nano-Vehicles for Potential pH-Sensitive Nanomedicine Delivery
Yu, Hongyun
Mu, Hongjie
Xu, Lijie
Sun, Kaoxiang
Liu, Wanhui
Chen, Daquan
NANOSCIENCE AND NANOTECHNOLOGY LETTERS, 2013, 5 (09) : 1007 - 1011
[33] Fabrication of a novel pH-sensitive glutaraldehyde cross-linked pectin nanogel for drug delivery
Department of Pharmacy, Renmin Hospital, Wuhan University, Wuhan 430072, China
不详
J. Biomater. Sci. Polym. Ed., 2007, 12 (1591-1599):
[34] Preparation and characterization of a novel pH-sensitive coated microsphere for duodenum-specific drug delivery
Dan Zhou
Xi Zhu
Yang Wang
Yun Jin
Xuefan Xu
Tingting Fan
Yan Liu
Zhirong Zhang
Yuan Huang
Archives of Pharmacal Research, 2012, 35 : 839 - 850
[35] Novel polymerizable surfactants with pH-sensitive amphiphilicity and cell membrane disruption for efficient siRNA delivery
Wang, Xu-Li
Ramusovic, Sergej
Nguyen, Thanh
Lu, Zheng-Rong
BIOCONJUGATE CHEMISTRY, 2007, 18 (06) : 2169 - 2177
[36] Preparation and in vitro controlled release behavior of a novel pH-sensitive drug carrier for colon delivery
Xu, Dong-Ying
Li, Guang-Ji
Liao, Zheng-Fu
He, Xiao-Hong
POLYMER BULLETIN, 2009, 62 (02) : 183 - 193
[37] pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method
Laouini, Abdallah
Koutroumanis, Konstantinos P.
Charcosset, Catherine
Georgiadou, Stella
Fessi, Hatem
Holdich, Richard G.
Vladisavljevic, Goran T.
ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (18) : 8939 - 8947
[38] Preparation and in vitro controlled release behavior of a novel pH-sensitive drug carrier for colon delivery
Dong-Ying Xu
Guang-Ji Li
Zheng-Fu Liao
Xiao-Hong He
Polymer Bulletin, 2009, 62 : 183 - 193
[39] Fabrication of a novel pH-sensitive glutaraldehyde cross-linked pectin nanogel for drug delivery
Chang, Cong
Wang, Zong-Chun
Quan, Chang-Yun
Cheng, Han
Cheng, Si-Xue
Mang, Xjan-Zheng
Zhuo, Ren-Xi
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2007, 18 (12) : 1591 - 1599
[40] Preparation and characterization of a novel pH-sensitive coated microsphere for duodenum-specific drug delivery
Zhou, Dan
Zhu, Xi
Wang, Yang
Jin, Yun
Xu, Xuefan
Fan, Tingting
Liu, Yan
Zhang, Zhirong
Huang, Yuan
ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (05) : 839 - 850

← 1 2 3 4 5 →