Efficient ligand-free copper-catalyzed C-S cross-coupling of thiols with aryl iodides using KF/Al2O3 as base

被引：57
|
作者：
Feng, Yi-Si [1 ,2 ]
Li, Yuan-Yuan [1 ]
Tang, Lin [1 ]
Wu, Wei [1 ]
Xu, Hua-Jian [1 ,2 ]
机构：
[1] Hefei Univ Technol, Sch Chem Engn, Hefei 230009, Peoples R China
[2] Anhui Key Lab Controllable Chem React & Mat Chem, Hefei 230009, Peoples R China
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 18期
基金：
中国国家自然科学基金;
关键词：
SULFUR BOND FORMATION; PHOSPHINE OXIDE LIGAND; IMPROVED PROTOCOL; HIGHLY EFFICIENT; RECENT PROGRESS; BORONIC ACIDS; SOLUBLE BASE; HALIDES; CARBON; THIOETHERS;
D O I：
10.1016/j.tetlet.2010.02.155
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a mild, convenient, environmentally friendly, and ligand-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI with KF/Al2O3 as the base, in DMF at 110 degrees C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and Olio's. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2489 / 2492
页数：4
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