A pH sensitive fluorescent cyanine dye for biological applications

被引：101
|
作者：
Briggs, MS [1 ]
Burns, DD [1 ]
Cooper, ME [1 ]
Gregory, SJ [1 ]
机构：
[1] Amersham Pharmacia Biotech, Drug Discovery, Forest Farm, Cardiff CF14 7YT, S Glam, Wales
来源：
CHEMICAL COMMUNICATIONS | 2000年 / 23期
关键词：
D O I：
10.1039/b007108k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A pentamethine cyanine dye has been synthesised that is fluorescent when protonated, becoming non-fluorescent upon proton abstraction. The probe has a pK(a) of 7.5, with observable changes in the fluorescent emission properties across a pH range of 6.0-8.0, therefore providing a useful probe for studying pH in biological media.
引用
收藏
页码：2323 / 2324
页数：2
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