Synthesis and cytotoxicity of novel fatty acid-nucleoside conjugates

被引：9
|
作者：
Zhang, Yun-Xiao [1 ]
Dai, Gui-Fu [1 ]
Wang, Le [1 ]
Tao, Jing-Chao [1 ]
机构：
[1] Zhengzhou Univ, New Drug Res & Dev Ctr, Dept Chem, Zhengzhou 450052, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 06期
关键词：
tegafur; fatty acid; conjugates; synthesis; cytotoxicity;
D O I：
10.1016/j.bmcl.2006.12.092
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
N3-Hydroxyethyltegafur (3) was synthesized in 91.0% yield under a new condition. A series of novel fatty acid esters of 3 were synthesized. These fatty acid-nucleoside conjugates have shown cytotoxicities against Ec9706 cells and A549 cells, and the structure activity relationship was discussed. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1613 / 1615
页数：3
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